{"id":55874,"date":"2006-04-12T00:00:00","date_gmt":"2006-04-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-de-neuroproteccion-con-antioxidantes-polifenolicos\/"},"modified":"2006-04-12T00:00:00","modified_gmt":"2006-04-12T00:00:00","slug":"mecanismos-moleculares-de-neuroproteccion-con-antioxidantes-polifenolicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neuroanatomia-humana\/mecanismos-moleculares-de-neuroproteccion-con-antioxidantes-polifenolicos\/","title":{"rendered":"Mecanismos moleculares de neuroprotecci\u00f3n con antioxidantes polifen\u00f3licos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Campos Esparza Mar\u00eda Del Rosario <\/strong><\/h2>\n<p>En enfermedades neurodegenerativas cr\u00f3nicas y agudas se ha visto implicado el fen\u00f3meno de la excitotoxicidad. La sobreactivaci\u00f3n de los receptores del \u00e1cido glut\u00e1mico induce una entrada masiva de calcio, estr\u00e9s oxidativo y apoptosis, provocando muerte neuronal.     nosotros investigamos en un modelo in vitro si la mangiferina y la morina, dos antixoidantes de origen natural, son capaces de proteger a las neuronas de la muerte exitot\u00f3xica.     demostramos que la mangiferina y la morina a bajas concentraciones -del rango nm-, protegen de la muerte neuronal excitot\u00f3xica, actuando sobre la fosforilaci\u00f3n de quinasas, modulando el estr\u00e9s oxidativo, manteniendo estable el potencial mitocondrial e inhibiendo la activaci\u00f3n o liberaci\u00f3n de prote\u00ednas pro-apopt\u00f3ticas y factores de transcripci\u00f3n.     en este contexto proponemos a estos antioxidante de origen natural como agentes terap\u00e9uticos en el tratamiento del da\u00f1o neuronal agudo y cr\u00f3nico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares de neuroprotecci\u00f3n con antioxidantes polifen\u00f3licos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares de neuroprotecci\u00f3n con antioxidantes polifen\u00f3licos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Campos Esparza Mar\u00eda Del Rosario <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> S\u00e1nchez G\u00f3mez Mar\u00eda Victoria<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jorgina Strustegui <\/li>\n<li> Garc\u00eda delgado Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>jordi Alberch i vie (vocal)<\/li>\n<li>Elena Alberdi alfonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Campos Esparza Mar\u00eda Del Rosario En enfermedades neurodegenerativas cr\u00f3nicas y agudas se ha visto implicado el fen\u00f3meno [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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