{"id":55967,"date":"2006-12-12T00:00:00","date_gmt":"2006-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-de-nuevas-fluoroquinolonas-para-el-tratamiento-de-meningitis-experimental-causada-por-streptococcus-pneumoniae-multirresistente\/"},"modified":"2006-12-12T00:00:00","modified_gmt":"2006-12-12T00:00:00","slug":"evaluacion-de-nuevas-fluoroquinolonas-para-el-tratamiento-de-meningitis-experimental-causada-por-streptococcus-pneumoniae-multirresistente","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pediatria\/evaluacion-de-nuevas-fluoroquinolonas-para-el-tratamiento-de-meningitis-experimental-causada-por-streptococcus-pneumoniae-multirresistente\/","title":{"rendered":"Evaluaci\u00f3n de nuevas fluoroquinolonas para el tratamiento de meningitis experimental causada por streptococcus pneumoniae multirresistente"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Viioleta Rodr\u00edguez Cerrato <\/strong><\/h2>\n<p>La emergencia a nivel mundial de cepas de s.Pneumoniae resistentes a antibi\u00f3ticos ha tenido un impacto fundamental en el tratamiento de pacientes con meningitis, determinando la investigaci\u00f3n de nuevos antibi\u00f3ticos, como las nuevas fluroquinolonas, con potente actividad in vitro frente a s.Pneumoniae, incluyendo a cepas resistentes a antibi\u00f3ticos beta-lact\u00e1micos. La reciente descripci\u00f3n de cepas neumoc\u00f3cicas cl\u00ednicas tolerantes a la vancomicina puede complicar adicionalmente el manejo terap\u00e9utico de la meningitis causada por estas cepas. La elevada morbilidad y mortalidad de la meningitis neumoc\u00f3cica con la terapia antibi\u00f3tica disponible y recomendada actualmente resulta alarmante. La terapia con antibi\u00f3ticos que act\u00faan sobre la pared celular neumoc\u00edcica, como los beta-lact\u00e1micos, exacerba la respuesta inflamatoria del hu\u00e9sped en el espacio subaracnoideo. en contraste, el uso de antibi\u00f3ticos bactericidas no bacteriol\u00edticos, como las quinolonas, puede ser potencialmente ventajoso.  los estudios farmacodin\u00e1micos e antibi\u00f3ticos para pacientes con meningitis con dif\u00edciles de realizar, por lo que los modelos de meningitis experimental son particularmente \u00fatiles para evaluara la farmacocin\u00e9tica y famracodinamia de nuevos antibi\u00f3ticos, para predecir la potencial efectividad antibacteriana en el l\u00edquido cefalorraqu\u00eddeo (lcr) y, por lo tanto, para predecir los reg\u00edmenes terap\u00e9uticos m\u00e1s eficaces.     en este trabajo se han evaluado en animales de experimentaci\u00f3n el perfil farmacocin\u00e9tico-farmacodi\u00e1mico y la efectividad de una fluroquinolona (garenoxacino) en el tratamiento de meningitis cursada por una cepa altamente resistente a beta-lact\u00e1micos. Asimismo, se ha comparado la efectividad del garenoxacino frente a otra nueva quinolona (moxifloxacino) y frente a reg\u00edmenes antibi\u00f3ticos que incluyen vacomicina y una cefalosporina de tercera generaci\u00f3n para la terapia de miningitis experimental inducida por una cepa neumoc\u00f3cica multirresist<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n de nuevas fluoroquinolonas para el tratamiento de meningitis experimental causada por streptococcus pneumoniae multirresistente<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n de nuevas fluoroquinolonas para el tratamiento de meningitis experimental causada por streptococcus pneumoniae multirresistente <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Viioleta Rodr\u00edguez Cerrato <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Ruiz Contreras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Nogales <\/li>\n<li>ernesto \u00e1ngel Garc\u00eda l\u00f3pez (vocal)<\/li>\n<li>Jos\u00e9 Prieto prieto (vocal)<\/li>\n<li>julio Casal lomobos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Viioleta Rodr\u00edguez Cerrato La emergencia a nivel mundial de cepas de s.Pneumoniae resistentes a antibi\u00f3ticos ha tenido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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