{"id":55976,"date":"2006-12-12T00:00:00","date_gmt":"2006-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-inmunosupresor-de-la-miastenia-gravis-con-tacrolimus-fk506\/"},"modified":"2006-12-12T00:00:00","modified_gmt":"2006-12-12T00:00:00","slug":"tratamiento-inmunosupresor-de-la-miastenia-gravis-con-tacrolimus-fk506","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-pulmonar\/tratamiento-inmunosupresor-de-la-miastenia-gravis-con-tacrolimus-fk506\/","title":{"rendered":"Tratamiento inmunosupresor de la miastenia gravis con tacrolimus (fk506)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jamal Azem Abderrazek <\/strong><\/h2>\n<p>La miastenia gravis es una enfermedad autoinmune mediada por anticuerpos anti-receptor de acetilcolina del m\u00fasculo esquel\u00e9tico.  su tratamiento incluye: la timectomia y la inmunosupresi\u00f3n con los corticoides, la azatioprina y la ciclosporina. Estos inmunosupresores son efectivos, pero el manejo de los pacientes con miastenia gravis generalizada refractaria y con efectos adversos secundarios al tratamiento prolongado con corticoides contin\u00faa sin soluci\u00f3n. Tacrolimus (fk506) es un macr\u00f3lido parecido a la ciclosporina y con potente efecto inmunosupresor. Basados en prometedores resultados iniciales con este f\u00e1rmaco, hemos iniciado dos trabajos prospectivos tatando con tacrolimus a un grupo de pacientes afectos de miastenia gravis refractaria, en que no es posible reducir la dosis de prednisona y\/o presnetanimportantes efectos secundarios a la prednisona y\/o ciclosporina. el primer estudio corresponde a un grupo de 15 pacientes, 2 fueron excluidos, uno por no cumplir los criterios de inclusi\u00f3n y el otro por decisi\u00f3n propia, los 13 incluidos completaron el estudio, todos timectomizados y afectos de miastenia gravis  refractaria al tratamiento con prednisona y cilosporina, que han sido tratados con tacrolimus (kf506) durante 12 meses a dosis de 0.1 mg\/kg de peso\/d\u00eda repartidos en dos tomas y ajustando la dosis en funci\u00f3n de los niveles plasm\u00e1ticos de este f\u00e1rmaco, para alcanzar concentraicones entre 7 y 8 ng\/ml. La dosis de prednisona se ha reducido progresivamente hasta retirarla. Los t\u00edtulos de los anticuperos anti-receptor de acetilcolina y la escala del grado de severidad de la miastenia gravis se han reducido de manera signifciativa y la fuerza muscular ha aumetnaod en un 37%.Todos los pacientes presentaron remisi\u00f3n farmacol\u00f3gica, 11 asintom\u00e1ticos y 2 con discreta ptosis palpebral. Tacrolimus fue bien tolerado y puede ser una alternativa en enfermos miastenicos que no responden a  los inmunosupresores convencionales. el segundo trabajo corresponde<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento inmunosupresor de la miastenia gravis con tacrolimus (fk506).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento inmunosupresor de la miastenia gravis con tacrolimus (fk506). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jamal Azem Abderrazek <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Armengol Carrasco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Navarro quilis <\/li>\n<li>merce Canela cardona (vocal)<\/li>\n<li> Bosch gil josep angel (vocal)<\/li>\n<li>Jos\u00e9 Gamez carbonell (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jamal Azem Abderrazek La miastenia gravis es una enfermedad autoinmune mediada por anticuerpos anti-receptor de acetilcolina del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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