{"id":55996,"date":"2006-12-12T00:00:00","date_gmt":"2006-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-neuroprotector-de-la-albumina-frente-a-las-acciones-deletereas-del-b-amiloide-en-neuronas-en-cultivo-primario\/"},"modified":"2006-12-12T00:00:00","modified_gmt":"2006-12-12T00:00:00","slug":"efecto-neuroprotector-de-la-albumina-frente-a-las-acciones-deletereas-del-b-amiloide-en-neuronas-en-cultivo-primario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/efecto-neuroprotector-de-la-albumina-frente-a-las-acciones-deletereas-del-b-amiloide-en-neuronas-en-cultivo-primario\/","title":{"rendered":"Efecto neuroprotector de la alb\u00famina frente a las acciones delet\u00e9reas del b amiloide en neuronas en cultivo primario"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Amable Vega Rasgado <\/strong><\/h2>\n<p>La patog\u00e9nesis de la enfermedad de alzheimer (ad) y otras enfermedades degenerativas a\u00fan no est\u00e1 esclarecido, pero se sabe que tienen en com\u00fan la agregaci\u00f3n anormal de prote\u00ednas. Particularmente, la ad se caracteriza por el dep\u00f3sito intra y extracelular de un p\u00e9ptido fibrilar aparentemente relacionado con la disfunci\u00f3n neuronal que eventualmente conduce a la demencia, llamado \u00edY amiloide (\u00edYa). el ba posee importancia como blanco terap\u00e9utico por varias razones, entre elias: 1) se presenta en las \u00abplacas seniles\u00bb, lesiones caracter\u00edsticas de ia ad; 2) es neurot\u00f3xico y 3) sus elevados niveles en mutaciones familiares en el gen que codifica la prote\u00edna precursora del ba (app) y en los genes de las presenilinas (enzimas involucradas en el procesamiento de la app). El ba normalmente se presenta en peque\u00f1as cantidades de forma soluble en cerebro, pero su posible papel fisiol\u00f3gico es oscuro. a\u00fan as\u00ed, el acumularse \u00edYa parece ser suficiente para causar demencia y se propone que este es un evento clave en la patog\u00e9nesis de la ad. En cualquier caso, el mecanismo por el cual el ba induce la muerte neuronal no se conoce completamente, y se requiere mayor comprensi\u00f3n del mismo para futuras intervenciones terap\u00e9uticas. diversas evidencias experimentales sugieren que uno de los posibles mecanismos de patigenicidad del \u00edYa es el estr\u00e9s \u00f3xidativo. Por otra parte, la diferenciaci\u00f3n neuronal parece influir en los efectos del \u00edYa, ya que el p\u00e9ptido presenta efectos tr\u00f3ficos en neuronas no diferenciadas, pero t\u00f3xicos en c\u00e9lulas maduras. estudios recientes reportan que la seroalb\u00famina promueve la supervivencia neuronal y mantiene el programa de diferenciaci\u00f3n celular, adem\u00e1s de ser un eficaz antioxidante. Por ello, cabr\u00eda esperar que la seroalb\u00famina tuviera efecto neuroprotector contra las acciones delet\u00e9reas del ab, y que dicha protecci\u00f3n se relacionara con la diferenciaci\u00f3n neuronal y\/o con la producci\u00f3n de radicales libres.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto neuroprotector de la alb\u00famina frente a las acciones delet\u00e9reas del b amiloide en neuronas en cultivo primario<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto neuroprotector de la alb\u00famina frente a las acciones delet\u00e9reas del b amiloide en neuronas en cultivo primario <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Amable Vega Rasgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Medina Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Reglero chillon <\/li>\n<li>eduardo Weruaga prieto (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda  oscar Prieto gonzalez (vocal)<\/li>\n<li>Mar\u00eda  Jes\u00fas Monte rio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Amable Vega Rasgado La patog\u00e9nesis de la enfermedad de alzheimer (ad) y otras enfermedades degenerativas a\u00fan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2148,115,9386],"tags":[4426,103353,7301,123696,123695,123697],"class_list":["post-55996","post","type-post","status-publish","format-standard","hentry","category-bioquimica-inmunologica","category-bioquimica-molecular","category-salamanca","tag-angel-reglero-chillon","tag-eduardo-weruaga-prieto","tag-jose-maria-medina-jimenez","tag-jose-maria-oscar-prieto-gonzalez","tag-lourdes-amable-vega-rasgado","tag-maria-jesus-monte-rio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=55996"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/55996\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=55996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=55996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=55996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}