{"id":56010,"date":"2018-03-09T22:43:43","date_gmt":"2018-03-09T22:43:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/viral-host-variability-during-hcv-chronic-infection\/"},"modified":"2018-03-09T22:43:43","modified_gmt":"2018-03-09T22:43:43","slug":"viral-host-variability-during-hcv-chronic-infection","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/virologia\/viral-host-variability-during-hcv-chronic-infection\/","title":{"rendered":"Viral-host variability during hcv chronic infection"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bihotz Fern\u00e1ndez Gonz\u00e1lez <\/strong><\/h2>\n<p>Numerosos aspectos de la infecci\u00f3n por parte del virus de la hepatitis c (hcv) no han sido dilucidados, como la relaci\u00f3n entre la frecuente falta de respuesta al tratamiento y la variabilidad viral o la aparici\u00f3n de importantes trastornos inmunol\u00f3gicos asociados a esta infecci\u00f3n.     el virus de la hepatitis c (vhc) se caracteriza por una gran variabilidad gen\u00e9tica. Vhc se peseta en el hospedador como una poblaci\u00f3n de variantes gen\u00e9ticamente diferentes pero pr\u00f3ximas y relacionadas denominadas cuasiespecies. A su vez, la regi\u00f3n hipervariable 1 (hvr1), localizada en el gen e2 del hcv presenta a su vez la m\u00e1xima plasticidad. Dentro del mismo gen, la regi\u00f3n pephd (pkr\/eif2alfa phosphorylation homology domain) presenta similaridad con el dominio de autofosforilaci\u00f3n de la enzima pkr y el factor de iniciaci\u00f3n de la transcripci\u00f3n del if2alfa. La cronificaci\u00f3n y la respuesta negativa al tratamiento pueden estar relacionada con la aparici\u00f3n de mutaciones. La complejidad gen\u00e9tica en ambas regiones fue analizada. La presencia de un bajo nivel de variabilidad puede ser una condici\u00f3n necesaria pero no indispensable para obtener una respuesta final positiva al tratamiento. La elevada variabilidad estar\u00eda relacionada a su vez, con un mejor fitness, con mayor capacidad replicativa y a su vez una mayor capacidad replicativa ya su vez una mayor variabilidad.     por otro lado, un descenso bif\u00e1sico del arn viral ha sido detectado en la mayor\u00eda de los pacientes. El efecto de la alta tasa mutacional del vhc en este descenso puede ser analizado mediante el empleo de modelos matem\u00e1ticos. en el presente trabajo se ha dise\u00f1ado un modelo matem\u00e1tico para analizar la din\u00e1mica viral de las cuasiespecies que forman parte de la poblaci\u00f3n viral. La simulaci\u00f3n matem\u00e1tica resultante indica que el tratamiento basado en la administraci\u00f3n de interfer\u00f3n pegilado mas ribavirina es un tratamiento muy fuerte capaz de revertir la competici\u00f3n entre las subpoblaciones pero<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Viral-host variability during hcv chronic infection<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Viral-host variability during hcv chronic infection <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bihotz Fern\u00e1ndez Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miren Basaras Ibarzabal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Regueiro garcia <\/li>\n<li>felipe Miguel de la villa (vocal)<\/li>\n<li>osvaldo Crivelli (vocal)<\/li>\n<li>carmen Ezpeleta baquedano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bihotz Fern\u00e1ndez Gonz\u00e1lez Numerosos aspectos de la infecci\u00f3n por parte del virus de la hepatitis c (hcv) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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