{"id":56066,"date":"2018-03-09T22:43:47","date_gmt":"2018-03-09T22:43:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/lipodistrofia-asociada-al-vih-factores-predisponentes-congenitos-adquiridos\/"},"modified":"2018-03-09T22:43:47","modified_gmt":"2018-03-09T22:43:47","slug":"lipodistrofia-asociada-al-vih-factores-predisponentes-congenitos-adquiridos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/enfermedades-infecciosas\/lipodistrofia-asociada-al-vih-factores-predisponentes-congenitos-adquiridos\/","title":{"rendered":"Lipodistrofia asociada al vih. factores predisponentes congenitos adquiridos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rego Fern\u00e1ndez Mar\u00eda  Carolina <\/strong><\/h2>\n<p>La lipodistrofia es una complicaci\u00f3n frecuente en los pacientes infectados por el vih en targa. Los antirretrovirales son importantes en su patog\u00e9nesis aunque factores heredados podr\u00edan jugar tambi\u00e9n alg\u00fan papel en su desarrollo. Hemos estudiado de forma prospectiva 243 pacientes caucasianos infectados por el vih en tratamiento antirretroviral seguidos en las consultas externas del hospital universitario central de asturias, oviedo. de ellos 11 eran na\u00ed\u00afve y 232 ven\u00edan recibiendo antirretrovirales durante una media de 93,3 +- 43,6 meses, y 79% recib\u00edan targa. tras 3 a\u00f1os de seguimiento 101 pacientes (41,6%) desarrollaron lipodistrofia. Hemos encontrado que el alelo t mutado del polimorfismo (+ 3954) de la il-1b era significativamente menos frecuente en los pacientes con lipodistrofia que en aquellos sin esta alteraci\u00f3n (18,8% frente a 28,9%, c2=5 ,47, or [ic95%] 0,57 [0,35 &#8211; 0,91], p=0,02). los niveles s\u00e9ricos de citoquinas eran m\u00e1s bajos en los portadores del alelo t de este polimorifsmo que en los pacientes con el genotipo cc. El tiempo de tratamiento con estavudina (p menor 0,001), uso de estavudina p menor 0,001), ausencia del alelo t del polimorfismo de la il-1b (+3954) (p=0,02), tener el diagn\u00f3stico de sida (p menor 0,001), nivel m\u00e1s bajo de cd4 (p=0,004), y tiempo de targa (p=0,008) se asociaron significativamente con lipodistrofia mediatne anova o c2. De estas variables, s\u00f3lo el tiempo de tratamiento con estavudina (p=0,001) y la ausencia del alelo t del polimorfismo de la il-1b (+3954) (p=0,017) se asociaron significativamente con lipodistrofia mediante regresi\u00f3n log\u00edstica. El genotipado del polimorfismo de il-1b (+3954) podr\u00eda ser de utilidad en los pacientes infectados por el vih que comienzan targa, para predecir su posible desarrollo de lipodistrofia, especialmente en aquellos usuarios potenciales de estavudina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lipodistrofia asociada al vih. factores predisponentes congenitos adquiridos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lipodistrofia asociada al vih. factores predisponentes congenitos adquiridos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rego Fern\u00e1ndez Mar\u00eda  Carolina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victor Asensi Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Arribas Castrillo Jos\u00e9 Manuel <\/li>\n<li>Esteban Martinez Chamorro (vocal)<\/li>\n<li>Santiago Moreno Guillen (vocal)<\/li>\n<li>Julio Collazos Gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rego Fern\u00e1ndez Mar\u00eda Carolina La lipodistrofia es una complicaci\u00f3n frecuente en los pacientes infectados por el vih [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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