{"id":56157,"date":"2018-03-09T22:43:51","date_gmt":"2018-03-09T22:43:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/activacion-linfocitaria-y-senalizacion-intracelular-mediada-por-cd6\/"},"modified":"2018-03-09T22:43:51","modified_gmt":"2018-03-09T22:43:51","slug":"activacion-linfocitaria-y-senalizacion-intracelular-mediada-por-cd6","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/activacion-linfocitaria-y-senalizacion-intracelular-mediada-por-cd6\/","title":{"rendered":"Activaci\u00f3n linfocitaria y se\u00f1alizaci\u00f3n intracelular mediada por cd6"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Ib\u00e1\u00f1ez Sanahuja <\/strong><\/h2>\n<p>Los linfocitos t se activan mediante la interacci\u00f3n del complejo tcr con un p\u00e9ptido antig\u00e9nico presentado por el mhc de la c\u00e9lula presentadora de ant\u00edgeno (apc). La baja afinidad de esta interacci\u00f3n ternaria se ve potenciada por la presencia de correceptores y otras mol\u00e9culas de membrana, que funciona para fortalecer la interacci\u00f3n y para translucir se\u00f1ales activadores al interior del linfocito t. La zona de contacto entre el lt y la c\u00e9lula presentadora (apc) se denomina sinapsis inmunitaria (si), y las mol\u00e9culas accesorias y de se\u00f1alizaci\u00f3n se van reorganizando formando una estructura denominada complejo supramolecular de asociaci\u00f3n (smac).     cd6 pertenece a la superfamilia de receptores con dominios ricos en ciste\u00ednas tipo scavenger (srcr, scavenger receptors cistein rich). El hecho que cd6 se asocie f\u00edsicamente al complejo cd3\/tcr y co-localiza con \u00e9l en la sinapsis inmunitaria, sit\u00faa a esta prote\u00edan en una posici\u00f3n \u00f3ptima para modular la se\u00f1alizaci\u00f3n mediada por el receptor de las c\u00e9lulas t, y por tanto participar en los procesos de activaci\u00f3n y diferenciaci\u00f3n de los linfocitos t. De acuerdo con esta hip\u00f3tesis, se ha demostrado que las se\u00f1ales mediadas por cd6 son esencialmente en las fases iniciales de la formaic\u00f3n y maduraci\u00f3n de la sinapsis inmunitaria y en las respuestas linfoproliferativas subsiguientes. De todos modos, las se\u00f1ales intracelulares mediadas por cd6 que influencian la activaci\u00f3n y maduraci\u00f3n de los linfocitos t son hasta el momento desconocidas. Este trabajo de tesis doctoral pretende ampliar los escasos  conocimientos existentes sobre esta prote\u00edna.     1,- estudio de las v\u00edas de se\u00f1alizaci\u00f3n intracelular, pro- y anti-apopt\u00f3ticas mediadas pro cd6.     en este trabajo de tesis nos planeamos el estudio de las v\u00edas de se\u00f1alizaci\u00f3n intracelular mediadas por el receptor linfocitario cd6, y m\u00e1s concretamente el an\u00e1lisis dela v\u00eda de se\u00f1alizaci\u00f3n de las map cinasas. La cascada de las map cinasas p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activaci\u00f3n linfocitaria y se\u00f1alizaci\u00f3n intracelular mediada por cd6<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activaci\u00f3n linfocitaria y se\u00f1alizaci\u00f3n intracelular mediada por cd6 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Ib\u00e1\u00f1ez Sanahuja <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Lozano Soto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Enric Espel Masferrer <\/li>\n<li>Dolors Colomer Pujol (vocal)<\/li>\n<li>Jos\u00e9 Yelamos Lopez (vocal)<\/li>\n<li> Rojo Hern\u00e1ndez Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Ib\u00e1\u00f1ez Sanahuja Los linfocitos t se activan mediante la interacci\u00f3n del complejo tcr con un p\u00e9ptido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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