{"id":56181,"date":"2018-03-09T22:43:51","date_gmt":"2018-03-09T22:43:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-diabetes-tipo-1-sobre-la-capacidad-reproductiva-masculina-estudio-experimental-en-rata\/"},"modified":"2018-03-09T22:43:51","modified_gmt":"2018-03-09T22:43:51","slug":"efecto-de-la-diabetes-tipo-1-sobre-la-capacidad-reproductiva-masculina-estudio-experimental-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/efecto-de-la-diabetes-tipo-1-sobre-la-capacidad-reproductiva-masculina-estudio-experimental-en-rata\/","title":{"rendered":"Efecto de la diabetes tipo 1 sobre la capacidad reproductiva masculina. estudio experimental en rata"},"content":{"rendered":"

Tesis doctoral de Laura Navarro Casado <\/strong><\/h2>\n

Objetivo: valorar la repercusi\u00f3n de la diabetes tipo 1 sobre la capacidad reproductiva masculina, en un modelo experimental en rata. material y m\u00e9todos: hemos empleado ratas macho sprague dawley con diabetes inducida por estreptozotocina (stz) en dos tiempos diferentes, 6 semanas (cp) y 20 semanas (mp). Como controles hemos empleado animales inyectados con veh\u00edculo y animales que tras la stz no se hicieron diab\u00e9ticos. Hemos analizado testosterona en suero (stt), reserva epididimaria de semen, alteraciones macrosc\u00f3picas y microsc\u00f3picas del test\u00edculo y epid\u00eddimo, s\u00edntesis in vitro de tt por homogeneizado de test\u00edculo tras digesti\u00f3n con colagenasa y bajo la acci\u00f3n de toxinas cholerae (tc) y pertussis (tp), hcg, glucosa, insulina y neurop\u00e9ptido y (npy). resultados: los animales diab\u00e9ticos presentaron disminuci\u00f3n en stt (p<0,01), peso de test\u00edculo (solo cp) y epid\u00eddimo (p<0,01), aumento en la teratozoospermia (s\u00f3lo mp, p<0,01) y disminuci\u00f3n del di\u00e1metro de los t\u00fabulos semin\u00edferos (cp, p<0,05). La glucosa aument\u00f3 la s\u00edntesis de tt en ausencia de hcg (p<0,05), la insulina no la modific\u00f3. Las c\u00e9lulas de los animales diab\u00e9ticos tuvieron mayor respuesta a la tc y a la hcg (p<0,05. El npy tiene efecto modulador negativo (p<0,01) o positivo (p<0,05) de la respuesta a la hcg dependiendo de la concentraci\u00f3n del mismo. La stz ocasion\u00f3 disminuci\u00f3n de la stt, peso epididimario y oligozoospermia (s\u00f3lo a cp, p<0,01; tambi\u00e9n produjo aumento de la s\u00edntesis basal de testosterona (solo cp, p<0,05). conclusiones: la diabetes experimental con stz origina una disminuci\u00f3n de la stt, aumento de teratozoospermia, disminuci\u00f3n en del peso del epid\u00eddimo y del test\u00edculo, aunque este \u00faltimo efecto revierte a mp. La funci\u00f3n de las c\u00e9lulas testiculares no est\u00e1 disminuida en la diabetes sino que est\u00e1 aumentada la respuesta a hcg y tc. El npy puede inhibir y estimular la s\u00edntesis in vitro de tt post hcg en funci\u00f3n de su concentraci\u00f3n en el medio de cultivo.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abEfecto de la diabetes tipo 1 sobre la capacidad reproductiva masculina. estudio experimental en rata<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la diabetes tipo 1 sobre la capacidad reproductiva masculina. estudio experimental en rata <\/li>\n
  • Autor:<\/strong>\u00a0 Laura Navarro Casado <\/li>\n
  • Universidad:<\/strong>\u00a0 Salamanca<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2006<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Jos\u00e9 Manuel Miralles Garcia<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Juan jose Corrales hernandez <\/li>\n
        • Jos\u00e9 Mar\u00eda Vendrell sala (vocal)<\/li>\n
        • margarita Ghiglione Juan es (vocal)<\/li>\n
        • Antonio Santiago Salinas sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Laura Navarro Casado Objetivo: valorar la repercusi\u00f3n de la diabetes tipo 1 sobre la capacidad reproductiva masculina, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1533,851,3761,9386],"tags":[124109,124107,66898,124108,124106,103352],"class_list":["post-56181","post","type-post","status-publish","format-standard","hentry","category-cirugia-urologica","category-endocrinologia","category-fisiologia-de-la-reproduccion","category-salamanca","tag-antonio-santiago-salinas-sanchez","tag-jose-manuel-miralles-garcia","tag-jose-maria-vendrell-sala","tag-juan-jose-corrales-hernandez","tag-laura-navarro-casado","tag-margarita-ghiglione-juan-es"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=56181"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56181\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=56181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=56181"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=56181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}