{"id":56202,"date":"2018-03-09T22:43:54","date_gmt":"2018-03-09T22:43:54","guid":{"rendered":""},"modified":"2018-03-09T22:43:54","modified_gmt":"2018-03-09T22:43:54","slug":"influencia-del-empleo-de-anticuerpos-monoclonales-y-bajas-dosis-de-inhibidores-de-la-calcineurina-en-el-postoperatorio-inmediato-del-trasplante-hepatico-con-fracaso-renal-agudo-identificacion-de-fact","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-de-trasplantes\/influencia-del-empleo-de-anticuerpos-monoclonales-y-bajas-dosis-de-inhibidores-de-la-calcineurina-en-el-postoperatorio-inmediato-del-trasplante-hepatico-con-fracaso-renal-agudo-identificacion-de-fact\/","title":{"rendered":"Influencia del empleo de anticuerpos monoclonales y bajas dosis de inhibidores de la calcineurina en el postoperatorio inmediato del trasplante hep\u00e1tico con fracaso renal agudo. identificaci\u00f3n de factores pron\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  L\u00f3pez Lago Ana Mar\u00eda <\/strong><\/h2>\n<p>La insuficiencia renal aguda (ira) supone un grave problema en el paciente trasplantado hep\u00e1tico (th); debido a su elevada incidencia (hasta un 51%) y a que su aparici\u00f3n incrementa la mortalidad hasta el 60% en pacientes que precisan t\u00e9cnicas dial\u00edticas en el postoperatorio del th. Los inhibidores de la calcineurina (ic) son nefrot\u00f3xicos; por ello es necesario elaborar estrategias inmunosupresoras encaminadas a disminuir el da\u00f1o renal.  objetivos     evaluar la introducci\u00f3n de una pauta de inducci\u00f3n consistente en disminuci\u00f3n am uy bajas dosis de los ic y la administraci\u00f3n de anticuerpos monoclonales anti cd25 con el fin de disminuir la agresi\u00f3n renal de la inmunosupresi\u00f3n standard. Se pretende conocer la incidencia, etiolog\u00eda y distribuci\u00f3n temporal de las infecciones y de los episodios de rechazo y p\u00e9rdida del injerto durante un per\u00edodo de seguimiento de un a\u00f1o post th y las necesidades de t\u00e9cnicas de depuraci\u00f3n extrarenal (de). Se evaluar\u00e1n los factores productivos de mortalidad, infecci\u00f3n y de t\u00e9cnicas dial\u00edticas y de ellos se determinar\u00e1n cuales lo son de forma independiente.  material y m\u00e9todo     estudio prospectivo. Realizado desde enero del 1999 hasta octubre del 2004. Se reclutaron 52 pacientes que presentaron ira durante el postoperatorio inmediato; \u00e9sta se defini\u00f3 como cretinita plasm\u00e1tica mayor o igual 1,5 mg\/dl, bun mayor o igual y\/o aclaramiento de creatinina (ac) menor o igual 50 ml\/min. A todos ellos se disminuyeron los niveles de tracrolimus hasta 5ngrs\/dl y se introdujeron anticuerpos anti cd25 (baxiliximab en 44 pacientes y daclizumab en 8). Se estudiaron variables del receptor (sexo, edad, etiolog\u00eda cirrosis, estadio funcional seg\u00fan child-pugh, apache, etc), del donante (causa de muerte, edad, grupo sangu\u00edneo, etc), intraoperatorias (t\u00c2\u00ba de isquemia, hemoderivados &#8230;), Anal\u00edticas, tales como cretinita plasm\u00e1tica, urea, ac, diuresis, got, gpt , ggt, fa, etc.  resultados     la supervivencia global al<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del empleo de anticuerpos monoclonales y bajas dosis de inhibidores de la calcineurina en el postoperatorio inmediato del trasplante hep\u00e1tico con fracaso renal agudo. identificaci\u00f3n de factores pron\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del empleo de anticuerpos monoclonales y bajas dosis de inhibidores de la calcineurina en el postoperatorio inmediato del trasplante hep\u00e1tico con fracaso renal agudo. identificaci\u00f3n de factores pron\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  L\u00f3pez Lago Ana Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Evaristo Varo P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaqu\u00edn Potel lesquereux <\/li>\n<li>alejandra Otero ferreiro (vocal)<\/li>\n<li>Manuel De la mata garcia (vocal)<\/li>\n<li>esteban Otero ant\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de L\u00f3pez Lago Ana Mar\u00eda La insuficiencia renal aguda (ira) supone un grave problema en el paciente trasplantado 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