{"id":56212,"date":"2018-03-09T22:43:54","date_gmt":"2018-03-09T22:43:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/propiedades-membrano-activas-e-inmunomoduladoras-de-la-protea%c2%adna-sp-c-del-surfactante-pulmonar-papel-del-segmento-n-terminal\/"},"modified":"2018-03-09T22:43:54","modified_gmt":"2018-03-09T22:43:54","slug":"propiedades-membrano-activas-e-inmunomoduladoras-de-la-protea%c2%adna-sp-c-del-surfactante-pulmonar-papel-del-segmento-n-terminal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/propiedades-membrano-activas-e-inmunomoduladoras-de-la-protea%c2%adna-sp-c-del-surfactante-pulmonar-papel-del-segmento-n-terminal\/","title":{"rendered":"Propiedades membrano-activas e inmunomoduladoras de la prote\u00edna sp-c del surfactante pulmonar: papel del segmento n-terminal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonz\u00e1lez Horta Azucena Del Carmen <\/strong><\/h2>\n<p>El surfactante pulmonar es una compleja mezcla lipoproteica que desarrolla dos funciones vitales. Primero el surfactante reduce la tensi\u00f3n superficial en los alv\u00e9olos disminuyendo el trabajo respiratorio y previniendo el colapso alveolar gracias a la interacci\u00f3n entre los fosfol\u00edpidos, l\u00edpidos neutros y las dos prote\u00ednas hidrof\u00f3bicas sp-b y sp-c. Estas prote\u00ednas promueven la formaci\u00f3n de una pel\u00edcula funcional de surfactante aumentado la adsorci\u00f3n y extensi\u00f3n en la interfase aire-l\u00edquido respiratoria de las mol\u00e9culas tensoactivas. segundo, el surfactante desarrolla funciones importantes asociadas al sistema inmune innato. La mayor\u00eda de estas actividades se han asignado a las prote\u00ednas hidrofilicas sp-a y sp-d, las cuales interaccionan directamente con pat\u00f3genos y alerfenos y estimulan c\u00e9lulas del sistema inmune. Una interacci\u00f3n directa entre la sp-c y lipopolisac\u00e1rido bacteriano ha sugerido la participaci\u00f3n de esta prote\u00edna en los mecanismos de defensa del pulm\u00f3n. El trabajo de investigaci\u00f3n desarrollada en la presente tesis ha tratado de caracterizar a nivel molecular el papel que el segmento n-terminal de la sp-c desempe\u00f1a en estas dos funciones empleando para ello peptidos sint\u00e9ticos que podr\u00edan potencialmente \u00fatiles como aditivos en nuevas preparaciones de surfactante cl\u00ednico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Propiedades membrano-activas e inmunomoduladoras de la prote\u00edna sp-c del surfactante pulmonar: papel del segmento n-terminal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Propiedades membrano-activas e inmunomoduladoras de la prote\u00edna sp-c del surfactante pulmonar: papel del segmento n-terminal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonz\u00e1lez Horta Azucena Del Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Perez Gil<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li>Luis Rivas l\u00f3pez (vocal)<\/li>\n<li>david Andreu mart\u00ednez (vocal)<\/li>\n<li>isamel Mingarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonz\u00e1lez Horta Azucena Del Carmen El surfactante pulmonar es una compleja mezcla lipoproteica que desarrolla dos funciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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