{"id":56215,"date":"2018-03-09T22:43:54","date_gmt":"2018-03-09T22:43:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-patogenicos-de-hipertrigliceridemia-dislipoproteinemia-y-riesgo-vascular-en-la-diabetes-mellitus-tipo-2\/"},"modified":"2018-03-09T22:43:54","modified_gmt":"2018-03-09T22:43:54","slug":"factores-patogenicos-de-hipertrigliceridemia-dislipoproteinemia-y-riesgo-vascular-en-la-diabetes-mellitus-tipo-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/factores-patogenicos-de-hipertrigliceridemia-dislipoproteinemia-y-riesgo-vascular-en-la-diabetes-mellitus-tipo-2\/","title":{"rendered":"Factores patog\u00e9nicos de hipertrigliceridemia, dislipoproteinemia y riesgo vascular en la diabetes mellitus tipo 2."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teresa Gonz\u00e1lez Alegre <\/strong><\/h2>\n<p>Se estudian diversos par\u00e1metros cl\u00ednicos, epidemiol\u00f3gicos y anal\u00edticos de la trigliceridemia en su relaci\u00f3n con la diabetes tipo 2 y la enfermedad vascular, sobre una muestra total de 150 pacientes con moderado grado de control de la glucemia (hb glicada menor 8%), ambulatorios, reclutados de las consultas externas de medicina interna del hospital virgen de la victoria de m\u00e1laga. Se incluyeron en los an\u00e1lisis de cuantificaci\u00f3n beta de las lipoproteinas plasm\u00e1ticas separadas por ultracentrifugaci\u00f3n secuencial, la cuantificaci\u00f3n de ldl peque\u00f1as y densas (quantimertrix), apolipoproteinas a1, b100, e c2, c3, diversas adipocitokinas (tnf alfa, adiponectina), homocisteina y varios polimorfismos de los genes lpl, lipc, apo e, cetp y grado de resistencia a la insulina cuantificado como homa, las principales concluisoens de esta tesis fueron: la interacci\u00f3n m\u00e1s potente de factores gen\u00e9ticos con valores lipoproteicos ha sido la del alelo h- del snip hind iii del gen de la lpl, cuyos portadores muestran valores menores de triglic\u00e9ridos totales, tg en vldl, ldl y hdl, menor concentraci\u00f3n deco de vldl y co de ldl peque\u00f1as y densas, apo b y c3 y mayores de co de hdl. la presencia del alelo b2 del sinp taq ib del gen de la cetp parece comportarse de forma protectora frente al desarrollo de resistencia a la insulina. La presencia del alelo a del promotor del gen del a lipasa hep\u00e1tica parece predisponer al padecimiento de la arteriopat\u00eda perif\u00e9rica. La presencia de hipertrigliceridemia en esta poblaci\u00f3n diab\u00e9tica correlaciona positivamente en el h\u00e1bito de fumar, la hipoadiponectinemia y homa mayor 3 y negativamente con el polimorfismo h- del gen de la lpl, en el an\u00e1lisis multivariante s\u00f3lo el h\u00e1bito de fumar y el homa mayor 3 mantienen la significaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores patog\u00e9nicos de hipertrigliceridemia, dislipoproteinemia y riesgo vascular en la diabetes mellitus tipo 2.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores patog\u00e9nicos de hipertrigliceridemia, dislipoproteinemia y riesgo vascular en la diabetes mellitus tipo 2. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teresa Gonz\u00e1lez Alegre <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Gonz\u00e1lez Santos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Gonzalez baron <\/li>\n<li>Jes\u00fas Millan nu\u00f1ez cortes (vocal)<\/li>\n<li>pedro Betancor le\u00f3n (vocal)<\/li>\n<li>\u00e1ngel del Palacio p\u00e9rez-medel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teresa Gonz\u00e1lez Alegre Se estudian diversos par\u00e1metros cl\u00ednicos, epidemiol\u00f3gicos y anal\u00edticos de la trigliceridemia en su relaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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