{"id":56288,"date":"2018-03-09T22:43:59","date_gmt":"2018-03-09T22:43:59","guid":{"rendered":""},"modified":"2018-03-09T22:43:59","modified_gmt":"2018-03-09T22:43:59","slug":"accion-biologica-de-las-moleculas-inflamatorias-en-celulas-de-musculo-liso-vascular-y-su-capacidad-pronostica-en-las-complicaciones-post-operatorias-tempranas-en-pacientes-diabeticos-y-aterosclerotico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-biologica-de-las-moleculas-inflamatorias-en-celulas-de-musculo-liso-vascular-y-su-capacidad-pronostica-en-las-complicaciones-post-operatorias-tempranas-en-pacientes-diabeticos-y-aterosclerotico\/","title":{"rendered":"Acci\u00f3n biol\u00f3gica de las mol\u00e9culas inflamatorias en c\u00e9lulas de m\u00fasculo liso vascular y su capacidad pron\u00f3stica en las complicaciones post-operatorias tempranas en pacientes diab\u00e9ticos y ateroscler\u00f3ticos sometidos a cirugia de revascularizaci\u00f3n  mioc\u00e1rdica &#8211; estudio translacional &#8211;"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gordillo Moscoso Antonio  Augusto <\/strong><\/h2>\n<p>Introducci\u00f3n     la dm es una epidemia mundial y comparte con la aterosclerosis etiopatogenia, evoluci\u00f3n y tratamiento. A\u00fan existe alto riesgo de complicaciones post-revascularizaci\u00f3n quir\u00fargica coronaria, cuya relaci\u00f3n con el proceso inflamatorio pro-aterog\u00e9nico se desconoce.  objetivos     determinar asociaci\u00f3n entre marcadores de inflamaci\u00f3n, factores de riesgo, consumo de medicamentos y vino en pacientes ateroscler\u00f3ticos. Estudiar la remodelaci\u00f3n vascular en dm. Determinar capacidad pronostica de los marcadores de inflamaci\u00f3n en las complicaciones post-operatorias.  pacientes y m\u00e9todos     estudio translacional: cohorte de sufrimiento de complicaciones post- revascularizaci\u00f3n quir\u00fargica de miocardio. An\u00e1lisis de la expresi\u00f3n de prote\u00ednas pro-inflamatorias en tejido arterial y cmlv. Experimentaci\u00f3n con f\u00e1rmacos. An\u00e1lisis de apoptosis y proliferaci\u00f3n celular.  resultados     se reclutaron 116 pacientes, 15% mujeres, 44% diab\u00e9ticos, 55% hipertenso, 59% hiperlipid\u00e9micos y 33% fumadores activos. Por an\u00e1lisis multivariable se correlacionaron: pc-r, il-6, fibrin\u00f3geno, iam reciente, consumo de vino, hdl-colesterol y escala euroscore. no hubo asociaci\u00f3n entre medicamentos consumidos y marcadores de inflamaci\u00f3n. Se observ\u00f3 mayor inflamaci\u00f3n, apoptosis y proliferaci\u00f3n en arterias y cmlv de pacientes diab\u00e9ticos. Hubo 30 episodios de complicaciones mayores durante el seguimiento, no hubo diferencias entre diab\u00e9ticos y no diab\u00e9ticos. Las variables predictoras con significancia estad\u00edstica fueron: tabaquismo actual, puntuaci\u00f3n del euroescore e iam reciente.  conclusiones     los hallazgos del estudio apoyan la teor\u00eda inflamatoria de la ateroesclerosis. Los niveles de marcadores s\u00e9ricos de inflamaci\u00f3n se asociaron entre si, a iam reciente, edad, consumo de vino y puntuaci\u00f3n euroscore. Se describe un nuevo mecanismo de da\u00f1o vascular en la diabetes, secundario a desequilibro en la remodelaci\u00f3n vascular. El consumo de ta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acci\u00f3n biol\u00f3gica de las mol\u00e9culas inflamatorias en c\u00e9lulas de m\u00fasculo liso vascular y su capacidad pron\u00f3stica en las complicaciones post-operatorias tempranas en pacientes diab\u00e9ticos y ateroscler\u00f3ticos sometidos a cirugia de revascularizaci\u00f3n  mioc\u00e1rdica &#8211; estudio translacional &#8211;<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acci\u00f3n biol\u00f3gica de las mol\u00e9culas inflamatorias en c\u00e9lulas de m\u00fasculo liso vascular y su capacidad pron\u00f3stica en las complicaciones post-operatorias tempranas en pacientes diab\u00e9ticos y ateroscler\u00f3ticos sometidos a cirugia de revascularizaci\u00f3n  mioc\u00e1rdica &#8211; estudio translacional &#8211; <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gordillo Moscoso Antonio  Augusto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M.t. Tejerina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Luis Tamargo men\u00e9ndez <\/li>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez correa (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gordillo Moscoso Antonio Augusto Introducci\u00f3n la dm es una epidemia mundial y comparte con la aterosclerosis etiopatogenia, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[124354,24766,4665,124355],"class_list":["post-56288","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-gordillo-moscoso-antonio-augusto","tag-jose-antonio-gonzalez-correa","tag-juan-luis-tamargo-menendez","tag-m-t-tejerina"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=56288"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56288\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=56288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=56288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=56288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}