{"id":56384,"date":"2018-03-09T22:44:10","date_gmt":"2018-03-09T22:44:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-molecular-del-gen-tgfbr1-en-cancer-colorrectal\/"},"modified":"2018-03-09T22:44:10","modified_gmt":"2018-03-09T22:44:10","slug":"analisis-molecular-del-gen-tgfbr1-en-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/analisis-molecular-del-gen-tgfbr1-en-cancer-colorrectal\/","title":{"rendered":"Analisis molecular del gen tgfbr1 en cancer colorrectal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Adela Castillejo Castillo <\/strong><\/h2>\n<p>En nucosa normal de colon, la v\u00eda de transducci\u00f3n de se\u00f1ales de tgfb funciona como un importante mecanismo celular de control del crecimiento y proliferaci\u00f3n. Es el sistema natural con actividad supresora de tumores m\u00e1s potente que se conoce. La inmensa mayor\u00eda de tumores colorrectales presentan alteraciones que implican una p\u00e9rdida de funci\u00f3n de esta v\u00eda. existen numerosos trabajos en la bibliograf\u00eda en los que se aborda el estudio pormenorizado de los diferentes elementos de esta v\u00eda de transducci\u00f3n de se\u00f1ales en c\u00e1ncer colorrectal. El receptor 1 de tgfb ha sido analizado molecularmente en diversos estudios, aunque casi siempre de un modo aislado. As\u00ed mismo, las series estudiadas muchas veces son limitadas en cuanto a n\u00famero de tumores lo cual dificulta la obtenci\u00f3n de conclusiones s\u00f3lidas. Posiblemente, de todos los elementos conocidos que participan en esta v\u00eda, el gen tgfbr1 es el menos estudiado en c\u00e1ncer colorrectal. en este escenario, el objetivo del presente trabajo de investigaci\u00f3n ha sido establecer la implicaci\u00f3n del gen tgfbr1 en c\u00e1ncer colorrectal, abordando el estudio molecular a diferentes niveles sobre una misma serie de casos. la presente tesis doctoral se estructura en dos vertientes claramente diferenciadas. Por una parte se realiza un exahustivo an\u00e1lisis sobre las alteraciones moleculares a nivel som\u00e1tico que acontecen en la muestra de tumores objeto de este estudio, y su correlaci\u00f3n con diferentes par\u00e1metros cl\u00ednicos y anatomo-patol\u00f3gicos. Por otro lado, se analizan diferentes polimorfismos gen\u00e9ticos en tgfbr1 para determinar su posible implicaci\u00f3n como factores de predisposici\u00f3n a c\u00e1ncer colorrectal, en un dise\u00f1o de estudio de tipo caso-control. Por \u00faltimo, se discuten otros resultados obtenidos como consecuencia del estudio de la asociaci\u00f3n entre diferentes variables cl\u00ednicas y anatomo-patol\u00f3gicas. los resultados del presente estudio indican que: a) el 28% de los tumores colorrectales presentan p\u00e9rdi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis molecular del gen tgfbr1 en cancer colorrectal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis molecular del gen tgfbr1 en cancer colorrectal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Adela Castillejo Castillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Carrato Mena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Ferragut rodriguez <\/li>\n<li> Garcia lora angel Miguel (vocal)<\/li>\n<li>Jos\u00e9 Javier Garcia ramirez (vocal)<\/li>\n<li>Miguel angel L\u00f3pez nevot (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Adela Castillejo Castillo En nucosa normal de colon, la v\u00eda de transducci\u00f3n de se\u00f1ales de tgfb funciona [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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