{"id":56418,"date":"2018-03-09T22:44:10","date_gmt":"2018-03-09T22:44:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilizacion-de-anta%c2%adgenos-recombinantes-para-el-diagnostico-serologico-de-la-candidiasis-invasora\/"},"modified":"2018-03-09T22:44:10","modified_gmt":"2018-03-09T22:44:10","slug":"utilizacion-de-anta%c2%adgenos-recombinantes-para-el-diagnostico-serologico-de-la-candidiasis-invasora","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia-clinica\/utilizacion-de-anta%c2%adgenos-recombinantes-para-el-diagnostico-serologico-de-la-candidiasis-invasora\/","title":{"rendered":"Utilizaci\u00f3n de ant\u00edgenos recombinantes para el diagn\u00f3stico serol\u00f3gico de la candidiasis invasora"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana La\u00edn Torre <\/strong><\/h2>\n<p>Los miembros del g\u00e9nero c\u00e1ndida, y especialmente c\u00e1ndida albicans, se a\u00edslan frecuentemente del tracto gastrointestinal y reproductivo de individuos sanos. Diversos factores, como la inmunosupresi\u00f3n, la edad, o la hospitalizaci\u00f3n prolongada, pueden producir una alteraci\u00f3n del equilibrio entre c\u00e1ndida como habitante sapr\u00f3fito y el hospedador, convirtiendo al hongo en pat\u00f3geno oportunista, y siendo capaz de causar infecciones que var\u00edan desde candidiasis superficiales a sist\u00e9micas o invasoras, cuando se produce una diseminaci\u00f3n hemat\u00f3gena del hongo, invadiendo \u00f3rganos y tejidos. Debido al aumento de la incidencia de la caniddiasis invasora, a su elevada mortalidad, y ante la falta de m\u00e9todos diagn\u00f3sticos definitivos, en los \u00faltimos a\u00f1os se ha realizado un importante esfuerzo investigador centrado en el desarrollo de nuevas pruebas diagnosticas. En este sentido, la serolog\u00eda y en concreto, la detecci\u00f3n de anticuerpos contra ant\u00edgenos ya conocidos como inmunog\u00e9nicos, o contra prote\u00ednas de la pared celular y\/o espec\u00edficas de la fase micelial de c.Albicans (asociada con la fase invasora del hongo) puede ser de utilidad en el diagn\u00f3stico.     el objetivo de este trabajo ha sido determinar la utilidad diagn\u00f3stica de la detecci\u00f3n de anticuerpos contra cinco ant\u00edgenos de c.Albicans (enolasa, als3, ece1, hyr1 y hwp1), mediante inmunoblotting y ensayo eliss, y su comparaci\u00f3n con la prueba de detecci\u00f3n de anticuerpos anti-micelio de c.Albicans, mediante inmunoflurescencia indirecta (if), recientemente comercializada por un laboratorio espa\u00f1ol. Los cinco ant\u00edgenos de c.Albicans se obtuvieron mediante clonaci\u00f3n de los genes codificantes y su expresi\u00f3n en un hu\u00e9sped procariota. Posteriormente se purificaron por cormatograf\u00eda de afinidad a n\u00edquel. La detecci\u00f3n de anticuerpos contra dichos ant\u00edgenos mediante inmunoblotting fue muy poco sensible; par\u00e1metro que se mejoro gracias al ensayo elisa. La utilidad diagn\u00f3stica de las distintas prueba<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilizaci\u00f3n de ant\u00edgenos recombinantes para el diagn\u00f3stico serol\u00f3gico de la candidiasis invasora<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilizaci\u00f3n de ant\u00edgenos recombinantes para el diagn\u00f3stico serol\u00f3gico de la candidiasis invasora <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana La\u00edn Torre <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ponton San Emeterio Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillermo Quind\u00f3s andr\u00e9s <\/li>\n<li>josep Guarro artigas (vocal)<\/li>\n<li>Jos\u00e9 Schneider fontan (vocal)<\/li>\n<li>josep Cano lira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana La\u00edn Torre Los miembros del g\u00e9nero c\u00e1ndida, y especialmente c\u00e1ndida albicans, se a\u00edslan frecuentemente del tracto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2727,1738,984,597,12909],"tags":[124635,13560,13001,124636,7013,5149],"class_list":["post-56418","post","type-post","status-publish","format-standard","hentry","category-anticuerpos","category-antigenos","category-levaduras","category-microbiologia-clinica","category-pais-vasco-euskal-herriko-unibertsitatea","tag-ana-lain-torre","tag-guillermo-quindos-andres","tag-jose-schneider-fontan","tag-josep-cano-lira","tag-josep-guarro-artigas","tag-ponton-san-emeterio-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=56418"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56418\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=56418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=56418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=56418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}