{"id":56483,"date":"2018-03-09T22:44:14","date_gmt":"2018-03-09T22:44:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-inmunohistoqua%c2%admico-del-patron-de-expresion-de-marcadores-moleculares-a-la-carcinogenesis-del-cancer-de-prostata-mediante-microarrays-tisulares\/"},"modified":"2018-03-09T22:44:14","modified_gmt":"2018-03-09T22:44:14","slug":"analisis-inmunohistoqua%c2%admico-del-patron-de-expresion-de-marcadores-moleculares-a-la-carcinogenesis-del-cancer-de-prostata-mediante-microarrays-tisulares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-urologica\/analisis-inmunohistoqua%c2%admico-del-patron-de-expresion-de-marcadores-moleculares-a-la-carcinogenesis-del-cancer-de-prostata-mediante-microarrays-tisulares\/","title":{"rendered":"An\u00e1lisis inmunohistoqu\u00edmico del patr\u00f3n de expresi\u00f3n de marcadores moleculares a la carcinog\u00e9nesis del cancer de pr\u00f3stata mediante microarrays tisulares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mireira Musquera Felip <\/strong><\/h2>\n<p>Introducci\u00f3n     el c\u00e1ncer de pr\u00f3stata (cp) es uno de los tumores s\u00f3lidos m\u00e1s frecuentes en el mundo occidental, y representa una patolog\u00eda importante en el campo de la urolog\u00eda. Actualmente, los marcadores pron\u00f3sticos utilizados son: el grado de diferenciaci\u00f3n de gelason, el estadio y psa. No obstante, ninguno de estos marcadores suficiente para predecir la evoluci\u00f3n de esta neoplasia, as\u00ed pacientes afectos de cp con las mismas caracter\u00edsticas anatomopatol\u00f3gicas pueden tener una evoluci\u00f3n diferentes. Necesitamos nuevos marcadores para poder realizar un mejor diagn\u00f3stico precoz, poder tomar la mejor decisi\u00f3n  terap\u00e9utica en cada caso y conocer mejor la evoluci\u00f3n de esta enfermedad. Los requisitos de un nuevo marcador son claros: tiene que tener una elevada sensibilidad, especificidad, ser econ\u00f3mico y reproducible. el conocimiento de las bases moleculares de la carcinog\u00e9nesis del cp abre las puertas a la identificaci\u00f3n de nuevos marcadores moleculares con los requisitos antes mencionados. Actualmente no disponemos de ning\u00fan marcador molecular con suficiente nivel de evidencia cient\u00edfica para poder ser usado en la pr\u00e1ctica cl\u00ednica diaria.  material y metodos     se ha realizado un estudio restrospectivo de 171 pacientes diagnosticados de cp localizado y tratados mediante prostatectomia radical, entre marzo de 1997 y enero de 1999, con un seguimiento medio de 9,34 a\u00f1os. Se ha realizado la revisi\u00f3n de las historias cl\u00ednicas y paralelamente se han confeccionado un total de 9 microarrays tisulares con tejido prostatico parafinado de archivo, construidos con una media de 2,98 cilindros de tejido tumoral por paciente (1-5) y un cilindro control, de tejido peritumoral. se ha analizado el patr\u00f3n de expresi\u00f3n inmunohistoqu\u00edmico y de marcadores moleculares que intervienen en diferentes v\u00edas de la carcinog\u00e9nesis, correlacionandolos con las caracter\u00edsticas anantomopatol\u00f3gicas de gleason y estadio; y con fracaso  bioqu\u00edmico.  en primer<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis inmunohistoqu\u00edmico del patr\u00f3n de expresi\u00f3n de marcadores moleculares a la carcinog\u00e9nesis del cancer de pr\u00f3stata mediante microarrays tisulares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis inmunohistoqu\u00edmico del patr\u00f3n de expresi\u00f3n de marcadores moleculares a la carcinog\u00e9nesis del cancer de pr\u00f3stata mediante microarrays tisulares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mireira Musquera Felip <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/12\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ferran Algaba Arrea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: xavier Rius cornado <\/li>\n<li> Ribal caparr\u00f3s m. Jos\u00e9 (vocal)<\/li>\n<li>josep Lloreta trull (vocal)<\/li>\n<li>lourdes Mengual brichs (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mireira Musquera Felip Introducci\u00f3n el c\u00e1ncer de pr\u00f3stata (cp) es uno de los tumores s\u00f3lidos m\u00e1s frecuentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1533],"tags":[84107,53909,124771,124769,124770,9781],"class_list":["post-56483","post","type-post","status-publish","format-standard","hentry","category-cirugia-urologica","tag-ferran-algaba-arrea","tag-josep-lloreta-trull","tag-lourdes-mengual-brichs","tag-mireira-musquera-felip","tag-ribal-caparros-m-jose","tag-xavier-rius-cornado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=56483"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56483\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=56483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=56483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=56483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}