{"id":56497,"date":"2007-09-01T00:00:00","date_gmt":"2007-09-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-estructura-y-actividad-biologica-de-heterociclos-ha%c2%adbridos-peptido-heterociclo-y-peptido-carbohidrato\/"},"modified":"2007-09-01T00:00:00","modified_gmt":"2007-09-01T00:00:00","slug":"sa%c2%adntesis-estructura-y-actividad-biologica-de-heterociclos-ha%c2%adbridos-peptido-heterociclo-y-peptido-carbohidrato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estereoquimica-y-analisis-conformacional\/sa%c2%adntesis-estructura-y-actividad-biologica-de-heterociclos-ha%c2%adbridos-peptido-heterociclo-y-peptido-carbohidrato\/","title":{"rendered":"S\u00edntesis, estructura y actividad biol\u00f3gica de heterociclos, h\u00edbridos p\u00e9ptido-heterociclo y p\u00e9ptido-carbohidrato"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Roberto Chicharro Mart\u00edn <\/strong><\/h2>\n<p>Las dos primeras partes de la tesis doctoral tratan sobre la s\u00edntesis, estudios estructurales y actividad biol\u00f3gica de h\u00edbridos p\u00e9ptido-molde y compuestos relacionados, donde como moldes hemos usado derivados parcialmente hidrogenados de isoquinolina y derivados de 3,6-dihidro-2h-pirano.     la estrategia a seguir consisti\u00f3 en combinar estructuras c\u00edclicas y heterociclos arom\u00e1ticos, similares a los que se encuentran ampliamente distribuidos en la naturaleza (carbohidratos, alcaloides, etc.) Con fragmentos de origen pept\u00eddico. En los h\u00edbridos as\u00ed generados, el resto no pept\u00eddico convenientemente funcionalidad sirvi\u00f3 como molde donde anclar cadenas pept\u00eddicas, con el objetivo de que \u00e9stas adoptaran conformaciones bien definidas. Los compuestos fueron interesantes desde el punto de vista farmacol\u00f3gico, al conjugar en una sola mol\u00e9cula las propiedades que presentan tanto los p\u00e9ptidos como los carbohidratos o heterociclos arom\u00e1ticos por separado.     los compuestos preparados fueron ensayados frente al a enzima calpa\u00edna obteniendo resultados brillantes, estando los valores de inhibici\u00f3n en el rango nanomolar tanto para los h\u00edbridos como para los derivados sin fragmento pept\u00eddico. Las calpa\u00ednas (ec 3.422.17) componen una familia de prote\u00ednas dependientes de calcio, pertenecientes al grupo de las ciste\u00edn proteasas neutras citos\u00f3licas, de las que en los mam\u00edferos se conocen 20 tipos. A su vez tambi\u00e9n se pueden clasificar seg\u00fan como se expresen ya sean en tejidos espec\u00edficos o de forma ubicua (u- y la m-calpa\u00edna). esta enzima desempe\u00f1a un papel importante  en varios procesos que catalizan la proteolisis de prote\u00ednas involucradas en el remodelado del citoesqueleto de la c\u00e9lula, modulan la se\u00f1al de transducci\u00f3n de prote\u00ednas implicadas en procesos de apoptosis, est\u00e1n implicadas en la progresi\u00f3n del ciclo celular, regulan la activaci\u00f3n de las prote\u00ednas encargadas de las s\u00edntesis de plaquetas, etc. En relaci\u00f3n a las funciones fisio<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis, estructura y actividad biol\u00f3gica de heterociclos, h\u00edbridos p\u00e9ptido-heterociclo y p\u00e9ptido-carbohidrato<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis, estructura y actividad biol\u00f3gica de heterociclos, h\u00edbridos p\u00e9ptido-heterociclo y p\u00e9ptido-carbohidrato <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Roberto Chicharro Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bernardo Herradon Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Yus astiz <\/li>\n<li>Francisco Bermejo (vocal)<\/li>\n<li>Juan  Jos\u00e9 Vaquero l\u00f3pez (vocal)<\/li>\n<li>carmen Cruzado m. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roberto Chicharro Mart\u00edn Las dos primeras partes de la tesis doctoral tratan sobre la s\u00edntesis, estudios estructurales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,29634,902],"tags":[31808,124802,124801,31000,5623,124800],"class_list":["post-56497","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-derivados-del-benceno","category-estereoquimica-y-analisis-conformacional","tag-bernardo-herradon-garcia","tag-carmen-cruzado-m","tag-francisco-bermejo","tag-juan-jose-vaquero-lopez","tag-miguel-angel-yus-astiz","tag-roberto-chicharro-martin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=56497"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56497\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=56497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=56497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=56497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}