{"id":56511,"date":"2007-10-01T00:00:00","date_gmt":"2007-10-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sobreexpresion-de-receptores-de-tirosina-kinasa-y-de-fosfatasas-de-la-proteina-tirosina-en-carcinoma-de-celulas-renales-como-diana-terapeutica\/"},"modified":"2007-10-01T00:00:00","modified_gmt":"2007-10-01T00:00:00","slug":"sobreexpresion-de-receptores-de-tirosina-kinasa-y-de-fosfatasas-de-la-proteina-tirosina-en-carcinoma-de-celulas-renales-como-diana-terapeutica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/sobreexpresion-de-receptores-de-tirosina-kinasa-y-de-fosfatasas-de-la-proteina-tirosina-en-carcinoma-de-celulas-renales-como-diana-terapeutica\/","title":{"rendered":"Sobreexpresion de receptores de tirosina kinasa y de fosfatasas de la proteina tirosina en carcinoma de c\u00e9lulas renales como diana terapeutica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lambea Sorrosal Julio Jos\u00e9 <\/strong><\/h2>\n<p>Introducci\u00f3n. los receptores de la tirosina kinasa (rtks) son receptores de membrana que se unen a factores de crecimiento, mediadores celulares, se\u00f1ales de diferenciaci\u00f3n. La uni\u00f3n con el ligando provoca la fosforilaci\u00f3n y activaci\u00f3n de segundos mensajeros hasta obtener una respuesta nuclear. El proceso se regula por la internalizaci\u00f3n en el endosoma celular de los receptores y la degradaci\u00f3n proteas\u00f3mica mediante la v\u00eda de la ubiquitinaci\u00f3n. Las fosfatasas de la prote\u00edna tirosina (ptps) defosforilan los rtks. En c\u00e9lulas tumorales hay una sobreexpresi\u00f3n de rtks y de ptps lo que hace que sean m\u00e1s agresivos. objetivos primarios \/ hip\u00f3tesis de trabajo demostrar la sobreexpresi\u00f3n de rtks y ptps en l\u00edneas celulares de carcinoma de c\u00e9lulas renales analizando egfr, erbb2, vegfr-1, vegfr-2, pdgfr-1, pdgfr-2, hgfr1, hgfr-2 (met, ron beta), tie-1, tie-2, axl, y lmw-ptp, ptp-lb, sh-ptp-l. material y m\u00e9todos utilizaremos 5 l\u00edneas celulares murinas de carcinoma de c\u00e9lulas renales (slr 20,21,22,24,25) en cultivo, facilitadas por el hillman cancer institute de la universidad de pittsburgh, y una l\u00ednea celular con comportamiento similar al tejido renal normal (hk). Mediante la t\u00e9cnica de western-blot determinaremos la sobreexpresi\u00f3n de las distintas rtks y ptps.  resultados en todas las l\u00edneas celulares de carcinoma renal estudiadas se observa sobreexpresi\u00f3n de egfr en un grado muy superior al resto de prote\u00ednas. Se observa sobreexpresi\u00f3n en todas las l\u00edneas de vegfr-2, met y ptp-lb. En cuatro l\u00edneas celulares sobreexpresi\u00f3n de her-2, ron y lmw-ptp. En tres l\u00edneas axl y sh-ptp. En dos l\u00edneas observamos sobreexpresi\u00f3n de vegfr-1.  conclusiones en todas las l\u00edneas celulares de carcinoma renal estudiadas se observa sobreexpresi\u00f3n de egfr, vegfr-2, met y ptp-lb. Her-2. Sobreexpresi\u00f3n de ron y lmw-ptp en cuatro l\u00edneas celulares. Sobreexpresi\u00f3n en tres l\u00edneas de axl y sh-ptp. Sobreexpresi\u00f3n en dos l\u00edneas de vegfr-1. el western-blot es u<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sobreexpresion de receptores de tirosina kinasa y de fosfatasas de la proteina tirosina en carcinoma de c\u00e9lulas renales como diana terapeutica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sobreexpresion de receptores de tirosina kinasa y de fosfatasas de la proteina tirosina en carcinoma de c\u00e9lulas renales como diana terapeutica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lambea Sorrosal Julio Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alejandro Tres Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Larrad mur <\/li>\n<li>valentin Del villar sordo (vocal)<\/li>\n<li> Valdivia uria Jos\u00e9 gabriel (vocal)<\/li>\n<li>Carlos Jara s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lambea Sorrosal Julio Jos\u00e9 Introducci\u00f3n. los receptores de la tirosina kinasa (rtks) son receptores de membrana que 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