{"id":56531,"date":"2007-12-01T00:00:00","date_gmt":"2007-12-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/litiacion-de-sustratos-difuncionalizados-quimioselectividad\/"},"modified":"2007-12-01T00:00:00","modified_gmt":"2007-12-01T00:00:00","slug":"litiacion-de-sustratos-difuncionalizados-quimioselectividad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/organometalicos\/litiacion-de-sustratos-difuncionalizados-quimioselectividad\/","title":{"rendered":"Litiacion de sustratos difuncionalizados: quimioselectividad"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Abdeslam Aboud <\/strong><\/h2>\n<p>La presente memoria trata sobre el estudio de los procesos de litiaci\u00f3n de diferentes sustratos difuncionalizados, usando litio en presencia de un areno como agente de litiaci\u00f3n y estando  el areno bien en cantidades estequiom\u00e9tricas (naftaleno, c10h8) o catal\u00edticas (4,4-di-terc-butilbifenilo, dtbb). Tambi\u00e9n se estudia la reacci\u00f3n posterior de los intermedios organol\u00edticos generados con electr\u00f3filos, y la influencia de la posici\u00f3n relativa de los grupos funcionales en los rendimientos obtenidos en todos estos procesos. Se ha estructurado esta memoria en cuatro bloques:     litiaci\u00f3n de clorofenilsulfanilcanos 2. Usando dos equivalentes de litio naftaleno, es posible llevar a cabo un amonolitiaci\u00f3n selectiva de los compuestos 2 por ruptura del enlace c-cl, permaneciendo el otro grupo funcional inalterado. La reacci\u00f3n posterior del intermedio organol\u00edtico generado con un compuesto carbon\u00edlico como electr\u00f3filo, condujo a la formaci\u00f3n de fenilsulfani alcoholes 5. Se pudo llevar a cabo una doble litiaci\u00f3n  reacci\u00f3n con elecr\u00f3filos de manera secuencial que permiti\u00f3 la introducci\u00f3n de dos electr\u00f3filos diferentes en el sustrato. Litiaci\u00f3n de bromcoloralcanos 1. Se ha estudiado tambi\u00e9n la monolitiaci\u00f3n selectiva de los bromocloralcanos 1 usando como agente de litiaci\u00f3n dos equivalentes de litio naftaleno. El proceso de litiaci\u00f3n debe realizarse en presencia de un compuesto carbon\u00edlico como electr\u00f3filo (condiciones barbier) debido a la gran inestabilidad del intermedio organol\u00edtico inicialmente generado. En este caso tiene lugar la ruptura reductora del enlace c-br de manera exclusiva, siendo los productos finales de reacci\u00f3n las clorohidrinas 11. Tambi\u00e9n se ha podido llevar acabo la doble litiaci\u00f3n, reacci\u00f3n con dos compuestos carbon\u00edlcios como electr\u00f3filos, obteni\u00e9ndose al fina los dioles no sim\u00e9tricos 8. Doble litiaci\u00f3n de alcanos 1,n-difuncinalizados. No ha sido posible llevar a cabo la monolitiaci\u00f3n selectiva de alcanos 1,n-difun<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Litiacion de sustratos difuncionalizados: quimioselectividad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Litiacion de sustratos difuncionalizados: quimioselectividad <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Abdeslam Aboud <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel \u00e1ngel Yus Astiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen N\u00e1jera domingo <\/li>\n<li>joaquin Plumet ortega (vocal)<\/li>\n<li>simeon Arseniyadis (vocal)<\/li>\n<li>Jos\u00e9 Manuel Concell\u00f3n gracia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Abdeslam Aboud La presente memoria trata sobre el estudio de los procesos de litiaci\u00f3n de diferentes sustratos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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