{"id":56533,"date":"2007-12-01T00:00:00","date_gmt":"2007-12-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/lesion-y-proteccion-de-las-celulas-beta-pancreaticas-en-el-trasplante-de-islotes-pancreaticos\/"},"modified":"2007-12-01T00:00:00","modified_gmt":"2007-12-01T00:00:00","slug":"lesion-y-proteccion-de-las-celulas-beta-pancreaticas-en-el-trasplante-de-islotes-pancreaticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/lesion-y-proteccion-de-las-celulas-beta-pancreaticas-en-el-trasplante-de-islotes-pancreaticos\/","title":{"rendered":"Lesi\u00f3n y protecci\u00f3n de las c\u00e9lulas beta pancre\u00e1ticas en el trasplante de islotes pancre\u00e1ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Montolio Rusi\u00f1ol <\/strong><\/h2>\n<p>El trasplante de islotes pancr\u00e1ticos podr\u00eda ser una buena terapia para los enfermos de diabetes mellitus de tipo 1, pero es necesario resolver algunos problemas antes que sea un tratamiento extendido. Uno de estos problemas es la limitada disponibilidad de \u00f3rganos, as\u00ed como la p\u00e9rdida de tejido trasplantado que se produce tanto por el rechazo del injerto como por el fallo del trasplante. Se sabe que en los primeros d\u00edas posteriores al trasplante se produce una p\u00e9rdida de aproximadamente el 60% de la masa beta trasplantada. Tambi\u00e9n se conoce que en el primer momento despu\u00e9s del trasplante se produce una respuesta inflamatoria inespec\u00edfica que podr\u00eda ser la responsable parcial de esta p\u00e9rdida.      el objetivo del estudio ha sido el de describir los fen\u00f3menos inflamatorios que se producen en el injerto en estos primeros d\u00edas. M\u00e1s concretamente, la expresi\u00f3n de citoquinas inflamatorias y su expresi\u00f3n estaba condicionada por el estado metab\u00f3lico del receptor del trasplante, as\u00ed como el efecto de la inhibici\u00f3n de la muerte por apoptosis de las c\u00e9lulas beta trasplantadas. Para eso se trasplantaron animales sing\u00e9nicos con una masa beta insuficiente para restablecer la normogluc\u00e9mia y se midi\u00f3 la expresi\u00f3n de diferentes citoquinas inflamatorias en el injerto. el primer d\u00eda despu\u00e9s del trasplante se produce una respuesta inflamatoria que da lugar a una elevada expresi\u00f3n de los genes de las citoquinas il-1beta, il-6, tnf-alfa y il-10, y se mantiene, aunque a niveles inferiores, durante la primera semana del trasplante.  en estos primeros d\u00edas tambi\u00e9n se detectan en el injerto las prote\u00ednas de il-1beta i de inos (principal mediador de la acci\u00f3n citot\u00f3xica de il-1beta), que principalmente las expresan los macr\u00f3fagos presentes en el injerto. La hipergluc\u00e9mia del receptor modifica de manera parcial la respuesta inflamatoria, aumentando la expresi\u00f3n de tnf-alfa, il-6 i il-10. Para examinar el efecto de la inhibici\u00f3n de la apoptosis, se tra<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lesi\u00f3n y protecci\u00f3n de las c\u00e9lulas beta pancre\u00e1ticas en el trasplante de islotes pancre\u00e1ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lesi\u00f3n y protecci\u00f3n de las c\u00e9lulas beta pancre\u00e1ticas en el trasplante de islotes pancre\u00e1ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Montolio Rusi\u00f1ol <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduard Montanya Mias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Bedoya bergua <\/li>\n<li>Juan  Francisco Merino torres (vocal)<\/li>\n<li>roser Casamitja abella (vocal)<\/li>\n<li>v\u00edctor Nacher Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Montolio Rusi\u00f1ol El trasplante de islotes pancr\u00e1ticos podr\u00eda ser una buena terapia para los enfermos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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