{"id":56567,"date":"2007-12-01T00:00:00","date_gmt":"2007-12-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variantes-alelicas-a640g-y-c242t-del-gen-cyba-p22phox-estudio-de-casos-controles-y-de-funcionalidad\/"},"modified":"2007-12-01T00:00:00","modified_gmt":"2007-12-01T00:00:00","slug":"variantes-alelicas-a640g-y-c242t-del-gen-cyba-p22phox-estudio-de-casos-controles-y-de-funcionalidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-cardiovascular\/variantes-alelicas-a640g-y-c242t-del-gen-cyba-p22phox-estudio-de-casos-controles-y-de-funcionalidad\/","title":{"rendered":"Variantes al\u00e9licas a640g y c242t del gen cyba (p22phox): estudio de casos controles y de funcionalidad"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mac\u00edas Reyes Antonio  Vicente <\/strong><\/h2>\n<p>La enfermedad cardiovascular es el mayor factor de morbimortalidad de nuestra sociedad occidental, y una de las causas que la provocan e inciden en su progresi\u00f3n es el da\u00f1o endotelial, mediado en parte por la excesiva de radicales del oxigeno principalmente por medio de la enzima nad(p)h oxidasa, que transfiere un electr\u00f3n al oxigeno desde la mol\u00e9cula de nad(p)h. La nad(p)h oxidasa es una enzima polim\u00e9rica formada por cinco prote\u00ednas principales, dos de las cuales se hallan ancladas en la membrana formando el citocromo b558.  De estas dos prote\u00ednas, una es p22phox, codificada por el gen cyba, cuyos niveles aumentados han sido relacionados con enfermedades prevalentes como la diabetes, la ateriosclerosis y la hipertensi\u00f3n. Algunos polimorfismos g\u00e9nicos de esta prote\u00edna, sobre todo c242t y a640g, han mostrado, aunque de forma diversa, en varios estudios de asociaci\u00f3n su relaci\u00f3n con la enfermedad cardiovascular. nuestro trabajo parte de un estudio casos\/control en poblaci\u00f3n canaria que encuentra una asociaci\u00f3n positiva entre el polimorfismo a640g de p22hox y la enfermedad cardiovascular. Esta asociaci\u00f3n se repite con el polimorfismo c242t, pero esta vez s\u00f3lo en mujeres. realizamos una serie de experimentos encaminados a medir la actividad nad(p)h oxidasa de estos sujetos agrupados por genotipos, tanto a nivel vascular como en monocitos\/macr\u00f3fagos, hallando una tendencia clara que soporta la asociaci\u00f3n citada. Igualmente, realizamos experimentos con los genotipos en b\u00fasqueda de una base fisiol\u00f3gicas que justificara lo hallado, y si bien no pudimos hallar diferencias en la durabilidad\/estabilidad del mrna que codifica para p22phoz entre genotipos, si encontramos que cuando se compara la cantidad de rna mensajero en individuos teherocig\u00f3ticos par a640g, se produce mayor cantidad de la cadena g que de la cadena a, pudiendo justificar este hecho una mayor actividad nad(p)h oxidasa en los individuos portadores de la cadena g.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variantes al\u00e9licas a640g y c242t del gen cyba (p22phox): estudio de casos controles y de funcionalidad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variantes al\u00e9licas a640g y c242t del gen cyba (p22phox): estudio de casos controles y de funcionalidad <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mac\u00edas Reyes Antonio  Vicente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodr\u00edguez Esparrag\u00f3n Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Betancor le\u00f3n <\/li>\n<li>armando Torres ram\u00edrez (vocal)<\/li>\n<li> Fern\u00e1ndez p\u00e9rez leandro Francisco (vocal)<\/li>\n<li>pablo Mart\u00edn vasallo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mac\u00edas Reyes Antonio Vicente La enfermedad cardiovascular es el mayor factor de morbimortalidad de nuestra sociedad occidental, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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