{"id":56591,"date":"2007-12-01T00:00:00","date_gmt":"2007-12-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-poblacional-de-metotrexato-en-ninos-con-leucemia-aguda-linfoblastica\/"},"modified":"2007-12-01T00:00:00","modified_gmt":"2007-12-01T00:00:00","slug":"farmacocinetica-poblacional-de-metotrexato-en-ninos-con-leucemia-aguda-linfoblastica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-accion-de-los-farmacos\/farmacocinetica-poblacional-de-metotrexato-en-ninos-con-leucemia-aguda-linfoblastica\/","title":{"rendered":"Farmacocin\u00e9tica poblacional de metotrexato en ni\u00f1os con leucemia aguda linfobl\u00e1stica"},"content":{"rendered":"

Tesis doctoral de Mar\u00eda Dolores Aumente Rubio <\/strong><\/h2>\n

El objetivo fue desarrollar y validar un modelo farmacocin\u00e9tico de poblaci\u00f3n para el metotrexate administrado a dosis altas en pacientes pedi\u00e1tricos diagnosticados de leucemia aguda linfobl\u00e1stica y establecer estrategias \u00f3ptimas de muestreo limitado utilizando m\u00e9todos bayesianos. Se incluy\u00f3 a 49 ni\u00f1os (6 meses a 17 a\u00f1os) que recibieron de 3 a 8 ciclos de metotrexato a dosis altas, 3g\/m2 en infusi\u00f3n de 24 horas o de 4 horas. La estimaci\u00f3n de los par\u00e1metros cin\u00e9ticos poblacionales se realiz\u00f3 con un grupo de 37 ni\u00f1os (171 ciclos; 1236 muestras) por el m\u00e9todo no lineal de efectos mixtos implementado en el programa nonmen y la validaci\u00f3n a priori del modelo propuesto con el resto de los pacientes (12 ni\u00f1os; 38 ciclos; 278 muestras). Finalmente la capacidad predictiva de los m\u00e9todos bayesianos se evalu\u00f3 en otro grupo de 14 pacientes (71 ciclos; 506 muestras) utilizando el programa abbottbase pksystem (pks). En el modelo final (bicompartimental) solo la edad y el peso total (tbw) tuvieron una influencia significativa sobre el aclaramiento (cl) y el volumen de distribuci\u00f3n del compartimento central (v1). Para los ni\u00f1os < (\u00f3 =)10 a\u00f1os: cl (l\/h) = 0.287*tbw0.876; v1 (l) = 0.465*tbw, y para los ni\u00f1os >10 a\u00f1os: cl (l\/h) = 0.149*tbw; v1 (l) = 0.437*tbw. Del modelo basal al final, la variabilidad interindividual disminuy\u00f3 un 30-50% para el cl y v1 en ambos grupos de edad. El coeficiente de variaci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos fue <30%, mientras la variabilidad residual y la inter-ocasi\u00f3n mantuvieron valores pr\u00f3ximos al 40%. La validaci\u00f3n interna del modelo propuesto result\u00f3 positiva lo que permite recomendarlo para su uso en cl\u00ednica y los tiempos de muestreo \u00f3ptimos seleccionados a trav\u00e9s de la validaci\u00f3n externa fueron: 1,6,23 y 36 horas cuando el metotrexato se perfunde en 24 horas y 8,19 y 24 horas en los ciclos de 4 horas.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abFarmacocin\u00e9tica poblacional de metotrexato en ni\u00f1os con leucemia aguda linfobl\u00e1stica<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica poblacional de metotrexato en ni\u00f1os con leucemia aguda linfobl\u00e1stica <\/li>\n
  • Autor:<\/strong>\u00a0 Mar\u00eda Dolores Aumente Rubio <\/li>\n
  • Universidad:<\/strong>\u00a0 Salamanca<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 12\/01\/2007<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • M\u00aa Jos\u00e9 Garc\u00eda S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n
        • Jos\u00e9 Suarez de lezo cruz conde (vocal)<\/li>\n
        • Mar\u00eda antonia Mangues bafaully (vocal)<\/li>\n
        • dolors Soy muner (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Mar\u00eda Dolores Aumente Rubio El objetivo fue desarrollar y validar un modelo farmacocin\u00e9tico de poblaci\u00f3n para el […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[483,9386],"tags":[3222,79784,2284,85157,125015,125016],"class_list":["post-56591","post","type-post","status-publish","format-standard","hentry","category-mecanismos-de-accion-de-los-farmacos","category-salamanca","tag-alfonso-jesus-dominguez-gil-hurle","tag-dolors-soy-muner","tag-jose-suarez-de-lezo-cruz-conde","tag-maria-antonia-mangues-bafaully","tag-maria-dolores-aumente-rubio","tag-ma-jose-garcia-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=56591"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56591\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=56591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=56591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=56591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}