{"id":56595,"date":"2018-03-09T22:44:21","date_gmt":"2018-03-09T22:44:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-fenotipico-y-protea%c2%b2mico-de-la-inhibicion-especa%c2%adfica-de-nf-kb-en-celulas-malignas-implicaciones-terapeuticas\/"},"modified":"2018-03-09T22:44:21","modified_gmt":"2018-03-09T22:44:21","slug":"analisis-fenotipico-y-protea%c2%b2mico-de-la-inhibicion-especa%c2%adfica-de-nf-kb-en-celulas-malignas-implicaciones-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-accion-de-la-quimioterapia\/analisis-fenotipico-y-protea%c2%b2mico-de-la-inhibicion-especa%c2%adfica-de-nf-kb-en-celulas-malignas-implicaciones-terapeuticas\/","title":{"rendered":"An\u00e1lisis fenotipico y prote\u00f3mico de la inhibici\u00f3n espec\u00edfica de nf-kb en c\u00e9lulas malignas: implicaciones terap\u00e9uticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Tapia Laliena Mar\u00eda \u00e1ngeles <\/strong><\/h2>\n<p>1,- papel de nf-b en la respuesta celular a la quimioterapia.     la familia de factores de transcripci\u00f3n nf-kb (p65\/rel-a, p105-p50\/nf-b1, p100-p52\/nf-b2, c-rel, relb) regula la expresi\u00f3n de genes que participan en varios procesos relacionados con el c\u00e1ncer, como la progresi\u00f3n del ciclo celular, la migraci\u00f3n, la adhesi\u00f3n celular y la apoptosis, pero es su papel en se\u00f1ales de supervivencia celular lo que realmente le implica en el desarrollo de quimioresistencia.     con el objetivo de avanzar en nuestro conocimiento sobre su papel en la quimioresistencia, uno de lso objetivos de esta tesis ha sido caracterizar la expresi\u00f3n de las prote\u00ednas de la v\u00eda nf-kb en l\u00edneas celulares de c\u00e1ncer de mama, pr\u00f3stata y pulm\u00f3n y su relaci\u00f3n con la diferentes respuesta a quimioter\u00e1picos actuales -doxorubicina, bortezombib, ps-1145, docetaxel y cisplatino-. Adem\u00e1s, se ha estudiado si la combinaci\u00f3n de doxorubicina con distintos inhibidores de la v\u00eda nf-kb -bortezomib, ps-1145, nemo-binding domain binding peptide- sensibiliza las c\u00e9lulas de c\u00e1ncer de mama al tratamiento, y tambi\u00e9n la contribuci\u00f3n individual de las subunidades nf-kb en este proceso mediante rna de interferencia (sirna).     en conclusi\u00f3n, la inhibici\u00f3n de nf-b sensibiliza a las l\u00edneas celulares estudiadas al tratamiento con doxorubicina y docetaxel, implicando directamente a las prote\u00ednas p65, p52, c-rel y nemo en la resistencia tumoral a la quimioterapia, pero no a la subunidad relb. Estos resultados demuestra que la inhibici\u00f3n selectiva de la v\u00eda can\u00f3nica de activaci\u00f3n de nf-kb es suficiente para mejorar los efectos antitumorales de estas drogas.     2,- efectos del inhibidor del proteasoma bortezomib en l\u00edneas de c\u00e1ncer de mama.     bortezomib (velcade, ps-341) es un nuevo inhibidor selectivo y reversible del proteasoma, cuya acci\u00f3n incluye la estabilizaci\u00f3n de prote\u00ednas reguladoras del ciclo celular, la inhibici\u00f3n de la activaci\u00f3n del factor nuclear kappa-b (nf-kb),<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis fenotipico y prote\u00f3mico de la inhibici\u00f3n espec\u00edfica de nf-kb en c\u00e9lulas malignas: implicaciones terap\u00e9uticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis fenotipico y prote\u00f3mico de la inhibici\u00f3n espec\u00edfica de nf-kb en c\u00e9lulas malignas: implicaciones terap\u00e9uticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Tapia Laliena Mar\u00eda \u00e1ngeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Albanell Mestres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: neus Agell jane <\/li>\n<li>joan Gil santano (vocal)<\/li>\n<li>gabriel Capella munar (vocal)<\/li>\n<li>joan Serratosa sard\u00ed\u00a0 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tapia Laliena Mar\u00eda \u00e1ngeles 1,- papel de nf-b en la respuesta celular a la quimioterapia. la familia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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