{"id":56714,"date":"2018-03-09T22:44:29","date_gmt":"2018-03-09T22:44:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-geneticos-en-la-enfermedad-hepatica-alcoholica\/"},"modified":"2018-03-09T22:44:29","modified_gmt":"2018-03-09T22:44:29","slug":"polimorfismos-geneticos-en-la-enfermedad-hepatica-alcoholica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-geneticos-en-la-enfermedad-hepatica-alcoholica\/","title":{"rendered":"Polimorfismos gen\u00e9ticos en la enfermedad hep\u00e1tica alcoh\u00f3lica"},"content":{"rendered":"

Tesis doctoral de Miguel Marcos Martin <\/strong><\/h2>\n

La enfermedad hep\u00e1tica alcoh\u00f3lica (eha) se desarrolla s\u00f3lo en un porcentaje (8-20%) de personas con un consumo excesivo de alcohol. Junto con la coexistencia de otros factores hepatot\u00f3xicos, la posesi\u00f3n determinados polimorfismos o variantes gen\u00e9ticas puede estar implicada en la variabilidad al desarrollo de esta enfermedad. estudiamos en 258 pacientes con ingesta excesiva de alcohol y criterios de abuso o dependencia de esta sustancia (161 sin eha y 97 con cirrosis hep\u00e1tica) y 101 controles con ingesta de alcohol menor de 10 gramos al d\u00eda los siguientes polimorfismos: 94ins\/delattg del gen nfkb1, 126g\/a nfkbia, 34c\/g pparg2, -238g\/a tnfa, 330t\/g il2, -33t\/c il4, -174g\/c il6, -251a\/t il8, -592c\/a il10 y 1188a\/c il12b. en alcoh\u00f3licos cirr\u00f3ticos respecto a alcoh\u00f3licos sin eha se encontr\u00f3 una mayor frecuencia del alelo a (genotipos ga y aa) del polimorfismo -238g\/a tnfa (p < 0,001, or 6,13 [2,65-14,29]); el metan\u00e1lisis realizado integrando estos datos con los de tres estudios previos confirm\u00f3 la asociaci\u00f3n significativa del alelo a con la eha, aunque todav\u00eda no existen datos claros sobre la funcionalidad de este polimorfismo en esta enfermedad. El alelo t (genotipos gt y tt) del polimorfismo -33t\/c il2 fue m\u00e1s frecuente en cirr\u00f3ticos que en alcoh\u00f3licos sin eha (p = 0,037, or = 4,20 [1,09-16,65]), sugiriendo que su posesi\u00f3n predispone el desarrollo de cirrosis a trav\u00e9s de la disminuci\u00f3n de la secreci\u00f3n de il-2. El alelo a (genotipos ca y aa) del -592c\/a il10 se encontr\u00f3 con mayor frecuencia en alcoh\u00f3licos que en controles (p = 0,048, or 1,65 [1,01-2,71]), pudiendo predisponer al desarrollo de alcoholismo a trav\u00e9s de una mayor inflamaci\u00f3n neuronal condicionada por la menor s\u00edntesis de il-10. No encontramos relaci\u00f3n para el resto de polimorfismos analizados con la presencia de cirrosis alcoh\u00f3lica o alcoholismo.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abPolimorfismos gen\u00e9ticos en la enfermedad hep\u00e1tica alcoh\u00f3lica<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos gen\u00e9ticos en la enfermedad hep\u00e1tica alcoh\u00f3lica <\/li>\n
  • Autor:<\/strong>\u00a0 Miguel Marcos Martin <\/li>\n
  • Universidad:<\/strong>\u00a0 Salamanca<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 22\/01\/2007<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Francisco Javier Laso Guzman<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: agustin Caro paton gomez <\/li>\n
        • joaquin Campos franco (vocal)<\/li>\n
        • arturo Gonzalez quintela (vocal)<\/li>\n
        • Jos\u00e9 Alberto Orfao de matos correia e vale (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Miguel Marcos Martin La enfermedad hep\u00e1tica alcoh\u00f3lica (eha) se desarrolla s\u00f3lo en un porcentaje (8-20%) de personas […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,11771,139,9386],"tags":[9694,51442,9719,125301,25781,125300],"class_list":["post-56714","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-genetica-clinica","category-medicina-interna","category-salamanca","tag-agustin-caro-paton-gomez","tag-arturo-gonzalez-quintela","tag-francisco-javier-laso-guzman","tag-joaquin-campos-franco","tag-jose-alberto-orfao-de-matos-correia-e-vale","tag-miguel-marcos-martin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=56714"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56714\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=56714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=56714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=56714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}