{"id":56732,"date":"2018-03-09T22:44:33","date_gmt":"2018-03-09T22:44:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-neurofarmacologicas-de-la-tolerancia-opiaceos-implicacion-de-la-va%c2%ada-del-oxido-na%c2%adtrico-en-el-locus-coeruleus\/"},"modified":"2018-03-09T22:44:33","modified_gmt":"2018-03-09T22:44:33","slug":"bases-neurofarmacologicas-de-la-tolerancia-opiaceos-implicacion-de-la-va%c2%ada-del-oxido-na%c2%adtrico-en-el-locus-coeruleus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacos-psicotropicos\/bases-neurofarmacologicas-de-la-tolerancia-opiaceos-implicacion-de-la-va%c2%ada-del-oxido-na%c2%adtrico-en-el-locus-coeruleus\/","title":{"rendered":"Bases neurofarmacol\u00f3gicas de la tolerancia opi\u00e1ceos: implicaci\u00f3n de la v\u00edadel \u00f3xido n\u00edtrico en el locus coeruleus"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Santamarta Lozano Mar\u00eda Teresa <\/strong><\/h2>\n<p>En primer lugar, se ha caracterizado, mediante registros electrofisiol\u00f3gicos uni-extracelulares, la desensibilizaci\u00f3n aguda de los receptores opioides inducida pro el agonista opioide met-encefalina (me) en las neuronas noradren\u00e9rgicas del lc de rata. As\u00ed, se ha determinado que esta desensibilizaci\u00f3n, que es concentraci\u00f3n-dependiente, se inhibe en presencia de f\u00e1rmacos inhibidores de la actividad \u00f3xido n\u00edtrico (no) sintasa de origen neuronal (7-nitroindazol, s-metil-l-tiocitrulina y n-propil-l-arginina) y se potencia con un f\u00e1rmaco donante de no (nitroprusiato s\u00f3dico). Se ha caracterizado, adem\u00e1s, la implicaci\u00f3n de la v\u00eda gmpc\/prote\u00edna cinasa dependiente de gpmc (pkg), principal v\u00eda fisiol\u00f3gica del no, en la desensibilizaci\u00f3n del receptor opioide inducida por me utilizando, para ello, f\u00e1rmacos que act\u00faan de manera selectiva sobre las enzimas de esta v\u00eda. Y as\u00ed, ni la activaci\u00f3n de las enzimas guanilato ciclasa soluble (gcs) o pkg por yc-1 y 8-br-gmpc, respectivamente, ni la inhibici\u00f3n de ambas enzimas, por odq y h8, modifican la desensibilizaci\u00f3n a una de los receptores opioides. Tambi\u00e9n se ha establecido que la aplicaci\u00f3n de un inhibidor de la s\u00edntesis de no neuronal in vivo (7-nitroindazol) aten\u00faa el desarrollo de tolerancia, tras un tratamiento subcr\u00f3nico con una emulsi\u00f3n oleasa de morfina, tanto al efecto electrosiiol\u00f3gico del agonista a opioide en el lc como al efecto anticonceptivo de opi\u00e1ceo morfina, determinado \u00e9ste con la t\u00e9cnica de retirada de la cola (tail-flick). En esta tesis se ha caracterizado adem\u00e1s la cin\u00e9tica de recambio (\u00abturnover\u00bb) funcional in vitro de los receptores opioide en neuronas noradren\u00e9rgicas del lc de cerebro de rata estudiando, adem\u00e1s, su modulaci\u00f3n por un tratamiento subcr\u00f3nico con opi\u00e1ceos y por no. Por \u00faltimo, se ha estudiado la implicaci\u00f3n del polip\u00e9tido activador en la enzima adenilato cilasa hipofisiaria (pacap) en las adaptaciones neuronales que tiene lugar tras el tratamiento cr\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases neurofarmacol\u00f3gicas de la tolerancia opi\u00e1ceos: implicaci\u00f3n de la v\u00edadel \u00f3xido n\u00edtrico en el locus coeruleus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases neurofarmacol\u00f3gicas de la tolerancia opi\u00e1ceos: implicaci\u00f3n de la v\u00edadel \u00f3xido n\u00edtrico en el locus coeruleus <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Santamarta Lozano Mar\u00eda Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pineda Ortiz Joseba Gotzon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosario Calvo duo <\/li>\n<li>Miguel Garcia navarro (vocal)<\/li>\n<li>pilar S\u00e1nchez blazquez (vocal)<\/li>\n<li>Luis Fernando Alguacil merino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santamarta Lozano Mar\u00eda Teresa En primer lugar, se ha caracterizado, mediante registros electrofisiol\u00f3gicos uni-extracelulares, la desensibilizaci\u00f3n aguda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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