{"id":56783,"date":"2018-03-09T22:44:33","date_gmt":"2018-03-09T22:44:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-poblacional-de-antirretroviales-en-rata\/"},"modified":"2018-03-09T22:44:33","modified_gmt":"2018-03-09T22:44:33","slug":"estudio-farmacocinetico-poblacional-de-antirretroviales-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/absorcion-de-los-farmacos\/estudio-farmacocinetico-poblacional-de-antirretroviales-en-rata\/","title":{"rendered":"Estudio farmacocin\u00e9tico poblacional de antirretroviales en rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Roc\u00edo Lled\u00f3 Garc\u00eda <\/strong><\/h2>\n<p>El saquinavir (sqv) y ritonavir (rtv), son f\u00e1rmacos antirretrovirales pertenecientes a la familia de inhibidores de la proteasa (ips), caracterizados por poseer una biodisponibilidad oral absoluta irregular, que  en el caso del saquinavir adem\u00e1s es baja. Ambos son substrato de enzimas metab\u00f3licas, como el cyp3a4 y de secreci\u00f3n intestinal. Actualmente, se utilizan en combinaci\u00f3n, ya que el ritonavir es un potente inhibidor de la isoenzima cyp3a4, de modo que aumenta la biodisponibilidad oral del saquinavir. objetivos pese a que  la interacci\u00f3n de sqv y rtv ya ha sido descrita en estudios previos, hasta la fecha, se desconoce la relevancia del h\u00edgado e intestino en el efecto de primer paso de estos f\u00e1rmacos. por ello, se han establecido los siguientes objetivos: -evaluar la linealidad cin\u00e9tica en los procesos del ladme del saquinavir, despu\u00e9s de la administraci\u00f3n de diferentes dosis del f\u00e1rmaco por v\u00eda iv, oral e ip. -calcular la biodisponibilidad oral e intraperitoneal del saquinavir y describir la importancia y localizaci\u00f3n del efecto de primer paso de saquinavir, tras su administraci\u00f3n por v\u00eda intraperitoneal y oral.-Describir en t\u00e9rminos farmacocin\u00e9ticos las posibles interacciones entre saquinavir y ritonavir, cuando se administran en combinaci\u00f3n.Materiales y m\u00e9todospara cumplir con los objetivos, se realizan ensayos in vivo, en los que ratas macho de la raza wistar se han sometido a la t\u00e9cnica de canulaci\u00f3n de la vena yugular. La valoraci\u00f3n de los f\u00e1rmacos en las muestras plasm\u00e1ticas purificadas se ha realizado mediante cromatograf\u00eda l\u00edquida de alta resoluci\u00f3n, utilizando un detector uv.Los datos se han sometido a un an\u00e1lisis no compartimental individual y como promedio simple de datos, mediante el programa inform\u00e1tico winnonlin(r) 4.1., Para evaluar la linealidad cin\u00e9tica y calcular la biodisponibilidad. A continuaci\u00f3n, los datos se han sometido a un an\u00e1lisis farmacocin\u00e9tico poblacional mediante el modelo no lineal de efect<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocin\u00e9tico poblacional de antirretroviales en rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocin\u00e9tico poblacional de antirretroviales en rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Roc\u00edo Lled\u00f3 Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Casab\u00f3 Al\u00f3s Vicente G.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marina Herr\u00e1ez sanz <\/li>\n<li>Francisco Otero espinar (vocal)<\/li>\n<li>rosario Calvo duo (vocal)<\/li>\n<li>Ana Mart\u00edn su\u00e1rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roc\u00edo Lled\u00f3 Garc\u00eda El saquinavir (sqv) y ritonavir (rtv), son f\u00e1rmacos antirretrovirales pertenecientes a la familia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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