{"id":5682,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/accion-de-la-ciclosporina-a-sobre-la-linea-fibroblastica-vero-y-su-relacion-con-la-sintesis-de-endotelina-y-fibrogenesis-colagena\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"accion-de-la-ciclosporina-a-sobre-la-linea-fibroblastica-vero-y-su-relacion-con-la-sintesis-de-endotelina-y-fibrogenesis-colagena","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/accion-de-la-ciclosporina-a-sobre-la-linea-fibroblastica-vero-y-su-relacion-con-la-sintesis-de-endotelina-y-fibrogenesis-colagena\/","title":{"rendered":"Accion de la ciclosporina a sobre la linea fibroblastica vero y su relacion con la sintesis de endotelina y fibrogenesis colagena."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lopez Hidalgo JavierLuis <\/strong><\/h2>\n<p>Actualmente existe controversia en el mecanismo de produccion de fibrogenesis colagena en los distintos organos de pacientes receptores de injertos sometidos a tratamiento con csa. En este sentido, no se conoce si la csa actua directa o indirectamente, a traves de mediadores inductores de fibrogenesis. Ademas el uso de farmacos puede desencadenar la respuesta frente a la agresion con modificacion de las proteinas de citoesqueleto, hsp y p-gp.  el trabajo se dise\u00f1o para cumplir los siguientes objetivos: estudiar las modificaciones que la csa produce en la proliferacion celular de la linea vero y en las proteinas del citoesqueleto, matriz extracelular, p-gp, moleculas relacionadas con el estres celular y principalmente sobre la sintesis colagena y la sintesis de endotelina.  la metodolog\u00eda empleada consistio en tecnicas de cultivo, de captacion de precursores timidina y prolina tritiados, radioinmunoanalisis, e inmunohistoquimica para citometria de flujo y tests colorimetricos con mtt.  conclusiones:  la linea vero expresa en condiciones basales masiva cantidad de vimentina y hsp-70, menor cantidad de hsp-25 y p-gp. Y sintesis de colageno tipo iv y endotelina.  el tratamiento con csa no produce efecto citotoxico hasta los 5ug\/ml, y a 1ug\/ml produce: incremento precoz de las hsp y vimentina asi como aumento de la secrecion de endotelina. La csa no produce directamente incremento de la sintesis de colageno.  por el contrario, la endotelina induce una fibrogenesis marcada en la linea vero a partir de las 48 horas acompa\u00f1ado de una notable diferenciacion celular.  todos los hechos demostrados permiten especular con la hipotesis de que la fibrosis asociada al tratamiento con csa depende esencialmente de una produccion incrementada de endotelina. El intenso estres producido por la csa podria relacionarse con la union especifica de este farmaco sobre el sistema de la ciclofilina y consiguiente respuesta adaptativa derivada de la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Accion de la ciclosporina a sobre la linea fibroblastica vero y su relacion con la sintesis de endotelina y fibrogenesis colagena.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Accion de la ciclosporina a sobre la linea fibroblastica vero y su relacion con la sintesis de endotelina y fibrogenesis colagena. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lopez Hidalgo JavierLuis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raimundo Garc\u00eda Delmoral Garrido<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: David Aguilar Pe\u00f1a <\/li>\n<li>Alfredo Blanes Berenguer (vocal)<\/li>\n<li>Jes\u00fas Egido De Los Rios (vocal)<\/li>\n<li>Sebastian Cerezo Morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lopez Hidalgo JavierLuis Actualmente existe controversia en el mecanismo de produccion de fibrogenesis colagena en los distintos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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