{"id":56839,"date":"2018-03-09T22:44:37","date_gmt":"2018-03-09T22:44:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estrategias-para-la-diferenciacion-in-vitro-de-celulas-es-de-raton-a-celulas-acinares-pancreaticas\/"},"modified":"2018-03-09T22:44:37","modified_gmt":"2018-03-09T22:44:37","slug":"estrategias-para-la-diferenciacion-in-vitro-de-celulas-es-de-raton-a-celulas-acinares-pancreaticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estrategias-para-la-diferenciacion-in-vitro-de-celulas-es-de-raton-a-celulas-acinares-pancreaticas\/","title":{"rendered":"Estrategias para la diferenciaci\u00f3n in vitro de c\u00e9lulas es de rat\u00f3n a c\u00e9lulas acinares pancre\u00e1ticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Meritxell Rovira Clusellas <\/strong><\/h2>\n<p>Las patolog\u00edas m\u00e1s importantes del p\u00e1ncreas exocrino, como la pancreatitis cr\u00f3nica (pc) o el c\u00e1ncer de p\u00e1ncreas, representan un gran problema de salud p\u00fablica en europa. En la pc, el tejido acinar es substituido por complejos ductales. Adem\u00e1s, es dif\u00edcil mantener el fenotipo diferenciado de las c\u00e9lulas acinares en cultivo ya que sufren una transdiferenciaci\u00f3n acinar-ductal. las c\u00e9lulas madre embrionarias (es) de rat\u00f3n han sido utilizadas en la \u00faltima d\u00e9cada para generar in vitro c\u00e9lulas completamente diferenciadas de varios linajes celulares. No obstante, la capacidad de las c\u00e9lulas es a diferenciarse a tipos celulares de origen endod\u00e9rmico es limitada. El objetivo principal de este proyecto ha consistido en desarrollar estrategias para diferenciar c\u00e9lulas es de rat\u00f3n a c\u00e9lulas pancre\u00e1ticas acinares con una elevada eficiencia mediante 1) la optimizaci\u00f3n de las condiciones de cultivo con tal de activar v\u00edas de se\u00f1alizaci\u00f3n implicadas en el desarrollo\/diferenciaci\u00f3n pancre\u00e1ticas; 2) la sobreexpresi\u00f3n de factores transcripcionales maestros utilizando vectores virales con el fin de recapitular espec\u00edficamente un programa de diferenciaci\u00f3n acinar; 3) la selecci\u00f3n gen\u00e9tica de las c\u00e9lulas comprometidas al linaje acinar con el objetivo de purificar las c\u00e9lulas acinares diferenciadas. mediante la integraci\u00f3n de estos abordajes, hemos conseguido aislar c\u00e9lulas que comparten caracter\u00edsticas fenot\u00edpicas con c\u00e9lulas acinares inmaduras seg\u00fan la expresi\u00f3n de marcadores de diferenciaci\u00f3n y la respuesta funcional a secretagogos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estrategias para la diferenciaci\u00f3n in vitro de c\u00e9lulas es de rat\u00f3n a c\u00e9lulas acinares pancre\u00e1ticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estrategias para la diferenciaci\u00f3n in vitro de c\u00e9lulas es de rat\u00f3n a c\u00e9lulas acinares pancre\u00e1ticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Meritxell Rovira Clusellas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/01\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Anouchka Skoudy<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lu\u00eds Herrera pedro <\/li>\n<li>angel Raya (vocal)<\/li>\n<li>francesc Miralles (vocal)<\/li>\n<li>thomas Graf (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Meritxell Rovira Clusellas Las patolog\u00edas m\u00e1s importantes del p\u00e1ncreas exocrino, como la pancreatitis cr\u00f3nica (pc) o el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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