{"id":56901,"date":"2007-05-02T00:00:00","date_gmt":"2007-05-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hepatotoxicidad-asociada-a-medicamentos-10-anos-de-experiencias-del-registro-espanol\/"},"modified":"2007-05-02T00:00:00","modified_gmt":"2007-05-02T00:00:00","slug":"hepatotoxicidad-asociada-a-medicamentos-10-anos-de-experiencias-del-registro-espanol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-clinicas\/hepatotoxicidad-asociada-a-medicamentos-10-anos-de-experiencias-del-registro-espanol\/","title":{"rendered":"Hepatotoxicidad asociada a medicamentos: 10 a\u00f1os de experiencias del registro espa\u00f1ol"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Garc\u00eda Ruiz <\/strong><\/h2>\n<p>Introducci\u00f3n     la hepatotoxicidad es una \u00abenfermedad hu\u00e9rfana\u00bb y escasamente reconocida debido a la ausencia de un \u00abpatr\u00f3n oro\u00bb diagn\u00f3stico y a la imposibilidad de conocer los mecanismos etiopatol\u00f3gicos. Sin embargo, es una de las principales causas de retirada del mercado de un medicamento.  objetivos     crear una red de hepatol\u00f3gos y farmac\u00f3logos cl\u00ednicos para recoger de forma prospectiva y estandarizada informaci\u00f3n sobre casos de hepatotoxicidad: detectar los grupos farmacol\u00f3gicos m\u00e1s frecuentes; y determinar factores de susceptibilidad al da\u00f1o hep\u00e1tico por f\u00e1rmacos, as\u00ed como de evoluci\u00f3n grave o fulminante.  m\u00e9todo     en 1994 se cre\u00f3 en espa\u00f1a un registro para recoger, mediante un protocolo estructurado y consensuado, los casos de hepatotoxicidad que tuvieran lugar en el entorno de las unidades colaboradoras. El da\u00f1o hep\u00e1tico se clasific\u00f3 en hepatocelular, colest\u00e1sico y mixto siguiendo criterios anal\u00edticos preestablecidos, salvo si exist\u00edan datos histol\u00f3gicos. Se aplic\u00f3 la escla cioms para la atribuci\u00f3n de causalidad.  resultados      desde abril de 1994 a agosto de 2004, 461 casos fueron incluidos. El grupo farmacol\u00f3gico m\u00e1s frecuente fue el de los antibi\u00f3ticos y el f\u00e1rmaco m\u00e1s veces implicado la amoxicilina-clavul\u00e1nico (12,8%). El da\u00f1o m\u00e1s frecuente fue el hepatocelular (58%) que se correlacion\u00f3 inversamente con la edad (p menor 0001) y tuvo peor evoluci\u00f3n  (regresi\u00f3n cox, p menor 034). En este grupo, los pacientes con ictericia en la presentaci\u00f3n, evolucionaron en un 11.7% a trasplante y muerte. El sexo femenino (p menor 0001), el da\u00f1o hepatocelular (p menor 009) y niveles plasm\u00e1ticos elevados de bilirrubina (p 001) se asociaron al desarrollo de fhf.  conclusiones     los pacientes con da\u00f1o hepatocelular e ictericia en la presentaci\u00f3n evolucionan en un 11,7% a trasplante o muerte. La amoxicilina-clavul\u00e1nico es el f\u00e1rmaco m\u00e1s frecuentemente asociado a hepatotoxicidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hepatotoxicidad asociada a medicamentos: 10 a\u00f1os de experiencias del registro espa\u00f1ol<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hepatotoxicidad asociada a medicamentos: 10 a\u00f1os de experiencias del registro espa\u00f1ol <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Garc\u00eda Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/02\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raul Jes\u00fas Andrade Bellido<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Gonz\u00e1lez santos <\/li>\n<li>alfonso Moreno gonzalez (vocal)<\/li>\n<li>joaqu\u00edn Fern\u00e1ndez-crehuet navajas (vocal)<\/li>\n<li>Juan Rod\u00e9s teixidor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Garc\u00eda Ruiz Introducci\u00f3n la hepatotoxicidad es una \u00abenfermedad hu\u00e9rfana\u00bb y escasamente reconocida debido a la ausencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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