{"id":56987,"date":"2007-12-02T00:00:00","date_gmt":"2007-12-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-poliaminoacidos-en-la-administracion-de-peptidos-y-protea%c2%adnas-de-interes-terapeutico\/"},"modified":"2007-12-02T00:00:00","modified_gmt":"2007-12-02T00:00:00","slug":"aplicacion-de-poliaminoacidos-en-la-administracion-de-peptidos-y-protea%c2%adnas-de-interes-terapeutico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/polipeptidos-y-proteinas\/aplicacion-de-poliaminoacidos-en-la-administracion-de-peptidos-y-protea%c2%adnas-de-interes-terapeutico\/","title":{"rendered":"Aplicaci\u00f3n de poliamino\u00e1cidos en la administraci\u00f3n de p\u00e9ptidos y prote\u00ednas de inter\u00e9s terap\u00e9utico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00f3scar Pe\u00f1a Gul\u00edn <\/strong><\/h2>\n<p>Los p\u00e9ptidos y prote\u00ednas se comienzan a tomar como importantes principios activos en el desarrollo de nuevos f\u00e1rmacos contra m\u00faltiples enfermedades. a pesar de ello, el material pept\u00eddico presenta muy baja biodisponibilidad, lo que supone un problema importante a la hora de dise\u00f1ar rutas de administraci\u00f3n. La industria farmac\u00e9utica ha dise\u00f1ado formas alternativas de administraci\u00f3n en las cuales juegan un papel importante los biopol\u00edmeros. Los poliamin\u00e1cidos son biopol\u00edmeros con alto potencial para el dise\u00f1o de nuevas formulaciones, sin embargo existen pocos ejemplos de estos \u00faltimos en desarrollo. Por ello, se ha planteado abrir un estudio sobre la aplicabilidad de ciertos poliamino\u00e1cidos (como el \u00e1cido poliglut\u00e1mico y la poliprolina) en la administraci\u00f3n de principios activos de tipo pept\u00eddico con fines terap\u00e9uticos.     en primer lugar, se puso a punto la metodolog\u00eda necesaria para la preparaci\u00f3n del \u00e1cido poliglut\u00e1mico y la poliprolina, as\u00ed como de sus precursores (preparaci\u00f3n de nalfa-carboxianh\u00eddridos). La manipulaci\u00f3n de macromol\u00e9culas de este trabajo exigi\u00f3 tambi\u00e9n un esfuerzo para su caracterizaci\u00f3n, acorde con las necesidades. Esto llev\u00f3 a utilizar las t\u00e9cnicas de dispersi\u00f3n de luz (light scattering) como pieza clave en la caracterizaci\u00f3n, tanto de pol\u00edmeros como de prote\u00ednas.     la manipulaci\u00f3n del \u00e1cido poliglut\u00e1mico permiti\u00f3 la obtenci\u00f3n de un derivado polim\u00e9rico funcionalizado (poliglu(cys)n) que permite su reticulaci\u00f3n en condiciones oxidantes, dando como resultado una matriz polim\u00e9rica de tipo hidrogel. Las propiedades quimico-fisicas estudiadas sugieren un alto potencial de este material para el dise\u00f1o de una formulaci\u00f3n de liberaci\u00f3n controlada para la administraci\u00f3n de p\u00e9ptidos y\/o prote\u00ednas.     los estudios de atrapamiento y liberaci\u00f3n de modelos p\u00e9ptidicos, en hidrogeles de poliglu(cys)n, confirmaron la capacidad de los hidrogeles descritos para albergar una prote\u00edna (como la hormo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n de poliamino\u00e1cidos en la administraci\u00f3n de p\u00e9ptidos y prote\u00ednas de inter\u00e9s terap\u00e9utico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n de poliamino\u00e1cidos en la administraci\u00f3n de p\u00e9ptidos y prote\u00ednas de inter\u00e9s terap\u00e9utico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00f3scar Pe\u00f1a Gul\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/02\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ernest Giralt Lledo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mercedes Alvarez domingo <\/li>\n<li>miriam Royo exp\u00f3sito (vocal)<\/li>\n<li>Mar\u00eda Blanco prieto (vocal)<\/li>\n<li> Vicent doc\u00f3n m. Jes\u00fas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00f3scar Pe\u00f1a Gul\u00edn Los p\u00e9ptidos y prote\u00ednas se comienzan a tomar como importantes principios activos en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,21662,396],"tags":[1100,125912,33523,1098,125911,125913],"class_list":["post-56987","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-espectroscopia-de-resonancia-magnetica","category-polipeptidos-y-proteinas","tag-ernest-giralt-lledo","tag-maria-blanco-prieto","tag-mercedes-alvarez-domingo","tag-miriam-royo-exposito","tag-oscar-pena-gulin","tag-vicent-docon-m-jesus"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56987","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=56987"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/56987\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=56987"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=56987"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=56987"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}