{"id":57002,"date":"2007-12-02T00:00:00","date_gmt":"2007-12-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-a-celula-neoplasica-y-de-la-translocacion-t922-en-leucemias-bcr-abl-correlacion-de-las-caractera%c2%adsticas-cla%c2%adnico-biologicas-de-la-enfermedad\/"},"modified":"2007-12-02T00:00:00","modified_gmt":"2007-12-02T00:00:00","slug":"caracterizacion-del-a-celula-neoplasica-y-de-la-translocacion-t922-en-leucemias-bcr-abl-correlacion-de-las-caractera%c2%adsticas-cla%c2%adnico-biologicas-de-la-enfermedad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hematologia\/caracterizacion-del-a-celula-neoplasica-y-de-la-translocacion-t922-en-leucemias-bcr-abl-correlacion-de-las-caractera%c2%adsticas-cla%c2%adnico-biologicas-de-la-enfermedad\/","title":{"rendered":"Caracterizaci\u00f3n del a c\u00e9lula neopl\u00e1sica y de la translocaci\u00f3n t(9,22) en leucemias bcr\/abl+: correlaci\u00f3n de las caracter\u00edsticas cl\u00ednico-biol\u00f3gicas de la enfermedad"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Primo Ramos <\/strong><\/h2>\n<p>Aunque la t(9;22) (q34;q11.2) que origina el gen de fusi\u00f3n bcr\/abl o cromosoma philadelfia (ph+) es el responsable neopl\u00e1sico de la leucemia mieloide cr\u00f3nica (lmc) y de un 20-30% de las leucemias linfobl\u00e1sticas agudas (lla), actualmente todav\u00eda permanecen muchas cuestiones por resolver.  en este trabajo de tesis doctoral hemos establecido la incidencia y significado gen\u00e9tico de las diferentes anomal\u00edas moleculares espec\u00edficas subyacentes que se producen en estos pacientes mediante t\u00e9cnicas de hibridaci\u00f3n in situ (fish), en una serie amplia de pacientes.   adem\u00e1s, dentro de las lla ph+ analizamos la incidencia de anomal\u00edas gen\u00e9ticas adicionales a la t(9;22) como la ganancia de un cromosoma ph extra, trisom\u00eda 8, monosom\u00eda 7 o deleciones a nivel de 9p21, las cuales se asociaron con caracter\u00edsticas cl\u00ednico-biol\u00f3gicas, fenot\u00edpicas y evolutivas concretas, determinando la del(9p21) un factor pron\u00f3stico nefasto en estos pacientes.  por su parte, dentro de las lmc observamos como hab\u00eda una afectaci\u00f3n mayoritaria de bcr\/abl dentro de las c\u00e9lulas precursoras y mieloides, aunque esta afectaci\u00f3n oscilaba dentro de los compartimentos linfoides. Sin embargo, observamos como aquellos pacientes con un reordenamiento mbcr\/abl se asociaron a un patr\u00f3n de afectaci\u00f3n com\u00fan de los linfocitos b y c\u00e9lulas nk.  finalmente, demostramos que dentro de la lmc, la expresi\u00f3n de bcr\/abl en precursores cd34+ mieloides est\u00e1 asociada a un aumento de la proliferaci\u00f3n celular, lo que no ocurre con las poblaciones de precursores mieloides cd34- m\u00e1s maduras, donde bcr\/abl podr\u00eda tener un efecto predominantemente anti-apopt\u00f3tico; estos hallazgos contribuir\u00edan a explicar la ausencia de una correlaci\u00f3n directa observada en esta tesis doctoral entre la expresi\u00f3n de bcr\/abl y el \u00edndice proliferativo de los distintos compartimentos de precursores mieloides ph+ de mo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del a c\u00e9lula neopl\u00e1sica y de la translocaci\u00f3n t(9,22) en leucemias bcr\/abl+: correlaci\u00f3n de las caracter\u00edsticas cl\u00ednico-biol\u00f3gicas de la enfermedad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del a c\u00e9lula neopl\u00e1sica y de la translocaci\u00f3n t(9,22) en leucemias bcr\/abl+: correlaci\u00f3n de las caracter\u00edsticas cl\u00ednico-biol\u00f3gicas de la enfermedad <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Primo Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/02\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marcos Gonzalez diaz <\/li>\n<li>Fernando Ramos ortega (vocal)<\/li>\n<li>josep Mar\u00eda Ribera santasusana (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Primo Ramos Aunque la t(9;22) (q34;q11.2) que origina el gen de fusi\u00f3n bcr\/abl o cromosoma philadelfia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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