{"id":57110,"date":"2018-03-09T22:44:54","date_gmt":"2018-03-09T22:44:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-moleculares-del-complejo-de-adhesion-cadherinas-cateninas-y-su-implicacion-en-el-cancer-de-mama\/"},"modified":"2018-03-09T22:44:54","modified_gmt":"2018-03-09T22:44:54","slug":"alteraciones-moleculares-del-complejo-de-adhesion-cadherinas-cateninas-y-su-implicacion-en-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/alteraciones-moleculares-del-complejo-de-adhesion-cadherinas-cateninas-y-su-implicacion-en-el-cancer-de-mama\/","title":{"rendered":"Alteraciones moleculares del complejo de adhesi\u00f3n cadherinas-cateninas y su implicaci\u00f3n en el c\u00e1ncer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sarri\u00f3 L\u00f3pez Jos\u00e9 David <\/strong><\/h2>\n<p>La desregulaci\u00f3n del complejo de adhesi\u00f3n cadherina-cateninas est\u00e1 \u00edntimamente relacionada con el g\u00e9nesis, desarrollo y progresi\u00f3n del c\u00e1ncer. Algunos de los componentes del complejo pueden actuar como supresores de tumores y de la invasi\u00f3n (cadherina-e), mientras que otros pueden funcionar como oncogenes (beta-catenina) o promotores de la met\u00e1stasis (cadherina-n). Adem\u00e1s, este sistema de adhesi\u00f3n est\u00e1 conectado con numerosas v\u00edas de se\u00f1alizaci\u00f3n celular (por ejemplo, la v\u00eda wnt\/beta-catenina), y por tanto, su alteraci\u00f3n promueve la oncog\u00e9neis, y progresi\u00f3n tumoral de diversas maneras. Para estudiar las alteraciones en el complejo de adhesi\u00f3n, sus causas, y las consecuencias que tienen sobre la biolog\u00eda de los diferentes tipos histol\u00f3gicos y genot\u00edpicos del c\u00e1ncer de mama, en la presente tesis se han utilizado diversas aproximaciones experimentales tanto in vitro como in vivo en biopsias tumorales. as\u00ed, en primer lugar, hemos determinado las alteraciones moleculares que provocan la p\u00e9rdida de cadherina-e en los carinomas lobulillares de mama desde las etapas pre-invasivas, y hemos demostrado que en este tipo histol\u00f3gico la ausencia de cadherina-e no inducela activaci\u00f3n de la v\u00eda oncog\u00e9nica de wnt, pero produce la localizaci\u00f3n n\u00facleo-citpl\u00e1smica de p120. Estas alteraciones podr\u00edan relacionares con el peculiar modo de invasi\u00f3n y patr\u00f3n de met\u00e1stasis de este tipo tumoral.  en segundo lugar, hemos determinado que la transici\u00f3n-epitelio-mes\u00e9nquima (tem), definida como la reducci\u00f3n de   caracter\u00edsticas epiteliales (incluida cadherina-e), junto con la inducci\u00f3n de marcadores mesenquim\u00e1ticos (incluyendo las cadherina -n y -11), ocurre preferiblemente en ciertos tumores de mama (carcinomas ductales de alto grado y carcinosarcomas) caracterizados por presentar un fenotipo varal\/mioepitelial. Asimismo, se presentan evidencias in vitro de la plasticidad fenot\u00edpica de c\u00e9lulas basales para transformarse en un fenotipo mesenquim\u00e1tico<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones moleculares del complejo de adhesi\u00f3n cadherinas-cateninas y su implicaci\u00f3n en el c\u00e1ncer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones moleculares del complejo de adhesi\u00f3n cadherinas-cateninas y su implicaci\u00f3n en el c\u00e1ncer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sarri\u00f3 L\u00f3pez Jos\u00e9 David <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/02\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Palacios Calvo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Rodr\u00edguez peralto <\/li>\n<li>Javier Ben\u00edtez ortiz (vocal)<\/li>\n<li>amparo Gano Garc\u00eda (vocal)<\/li>\n<li>Carlos Gamallo amat (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sarri\u00f3 L\u00f3pez Jos\u00e9 David La desregulaci\u00f3n del complejo de adhesi\u00f3n cadherina-cateninas est\u00e1 \u00edntimamente relacionada con el g\u00e9nesis, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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