{"id":57197,"date":"2018-03-09T22:44:58","date_gmt":"2018-03-09T22:44:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/synthesis-of-spiroisoquinolines-and-erythrinanes-based-on-intra-and-intermolecular-alfa-amidoalkylation-reactions\/"},"modified":"2018-03-09T22:44:58","modified_gmt":"2018-03-09T22:44:58","slug":"synthesis-of-spiroisoquinolines-and-erythrinanes-based-on-intra-and-intermolecular-alfa-amidoalkylation-reactions","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/synthesis-of-spiroisoquinolines-and-erythrinanes-based-on-intra-and-intermolecular-alfa-amidoalkylation-reactions\/","title":{"rendered":"Synthesis of spiroisoquinolines and erythrinanes based on intra- and intermolecular alfa-amidoalkylation reactions"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noori Abdullah Media <\/strong><\/h2>\n<p>En el trabajo de investigaci\u00f3n que se recoge en la presente memoria se ha investigado la aplicaci\u00f3n de las reacciones de alfa-amidoalquilaci\u00f3n y ciclaci\u00f3n parham para la s\u00edntesis de heterociclos nitrogenados, haciendo especial hincapi\u00e9 en el estudio de su estereoselectividad. As\u00ed, la ciclaci\u00f3n parham de n-fenetiltiazolidin-2,4-dionas con un sustituyente al\u00edlico en c-5 conduce de alfa-hidroxilactamas, precursores inmediatos de iones n-aciliminio bic\u00edclicos. La reacci\u00f3n de alfa-amidoalquilaci\u00f3n intermolecular empleando alliltrimethilsilano como nucle\u00f3filo conduce a 1,10b-trans tiazoloisoquinolinas con buen rendimiento y como un \u00fanico diasterois\u00f3mero. por otra parte, la alfa-amidoalquilaci\u00f3n intramolecular de n-fenetiltiazolidin-2,4-dionas no yodadas condujo 1,10b-cis tiazoloisoquinolinas como productos mayoritarios. Por tanto, ambas secuencias constituyen rutas diastereocomplementarias. Para mostrar la utilidad sint\u00e9tica de estas metodolog\u00edas, se ha desarrollado un nuevo procedimiento para la s\u00edntesis de derivados espiroisoquinol\u00ednicos, mediante una estrategia que implica la s\u00edntesis de una tiazoloisoquinolinas 1,10b-dialil sustituidad por aplicaci\u00f3n de la secuencia cilaci\u00f3n parham alfa, amidoalquilaci\u00f3n intermolecular, seguida de reacci\u00f3n de desulfurizaci\u00f3n. Por \u00faltimo, se ha estudiado una nueva ruta de eritrinanos en la que se realiza el cierre del anillo a en la \u00faltima etapa mediante estrategias que implicar\u00edan reacciones de adici\u00f3n conjugada inter o intramoleculares. Todos los intentos de introducir sustituyentes adecuadamente funcionalizados en c-10b mediante la secuencia adicci\u00f3n de reactivos organol\u00edticos funcionalizados, alfa-amidoalquilaci\u00f3n intramolecular, seguida de reacci\u00f3n de adici\u00f3n conjugada tambi\u00e9n intramolecular, fallaron. Sin embargo, hemos puesto a punto con \u00e9xito una nueva aproximaci\u00f3n sint\u00e9tica a eritrinanos, empleando reacciones de alfa-amidoalquilaci\u00f3n, adici\u00f3n conjugada y met\u00e1tesis intramolecular (rcm)<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Synthesis of spiroisoquinolines and erythrinanes based on intra- and intermolecular alfa-amidoalkylation reactions<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Synthesis of spiroisoquinolines and erythrinanes based on intra- and intermolecular alfa-amidoalkylation reactions <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noori Abdullah Media <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Esther Lete Exp\u00f3sito<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esther Dominguez perez <\/li>\n<li>anna Roglans ribas (vocal)<\/li>\n<li>Mar\u00eda Valpuesta fern\u00e1ndez (vocal)<\/li>\n<li>Jes\u00fas Manuel Peregrina Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noori Abdullah Media En el trabajo de investigaci\u00f3n que se recoge en la presente memoria se ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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