{"id":57209,"date":"2018-03-09T22:45:02","date_gmt":"2018-03-09T22:45:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reprogramacion-celular-de-celulas-embrionarias-de-raton-para-la-obtencion-de-celulas-productoras-de-insulina\/"},"modified":"2018-03-09T22:45:02","modified_gmt":"2018-03-09T22:45:02","slug":"reprogramacion-celular-de-celulas-embrionarias-de-raton-para-la-obtencion-de-celulas-productoras-de-insulina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/desarrollo-animal\/reprogramacion-celular-de-celulas-embrionarias-de-raton-para-la-obtencion-de-celulas-productoras-de-insulina\/","title":{"rendered":"Reprogramacion celular de celulas embrionarias de raton para la obtencion de celulas productoras de insulina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miriam Ramirez Dominguez <\/strong><\/h2>\n<p>La diabetes es una de las enfermedades cr\u00f3nicas m\u00e1s comunes del mundo, se calcula que un 6% de la poblaci\u00f3n espa\u00f1ola la padece y que un tercio de los diab\u00e9ticos no est\u00e1n diagnosticados. Hay varios tipos de diabetes, siendo las m\u00e1s comunes la diabetes tipo i la diabetes tipo ii. en este trabajo de investigaci\u00f3n nos hemos centrado en la diabetes tipo i, que es una enfermedad autoinmune en la que se destruyen selectivamente las c\u00e9lulas productoras de insulina del p\u00e1ncreas endocrino. El tratamiento tradicional para esta enfermedad ha sido la terapia con insulina ex\u00f3gena, as\u00ed como el trasplante de p\u00e1ncreas y ri\u00f1\u00f3n para los pacientes diab\u00e9ticos avanzados con nefropat\u00edas. Otras alternativas en fase experimental son: el trasplante de islotes, los xenotrasplantes, la obtenci\u00f3n de c\u00e9lulas beta a partir de la neog\u00e9nesis y el trasplante de c\u00e9lulas productoras de insulina, centr\u00e1ndonos en este \u00faltimo caso en las c\u00e9lulas derivadas in vitro de las c\u00e9lulas madre embrionarias. para esto \u00faltimo la presente tesis ha planteado el  desarrollo de un sistema de reprogramaci\u00f3n celular en c\u00e9lulas madre embrionarias de rat\u00f3n. Dado que la c\u00e9lula beta no posee factores de transcripci\u00f3n espec\u00edficos como para poder dise\u00f1ar un protocolo eficaz de diferenciaci\u00f3n  dirigida, se ha procedido a introducir en las c\u00e9lulas madre embrionarias de rat\u00f3n d3 (c\u00e9lulas diana) una mezcla de dichos factores procedentes de unas c\u00e9lulas donante para inducir en un contexto endod\u00e9rmico el gen de la insulina i. El m\u00e9todo desarrollado supone un paso m\u00e1s respecto al descrito en la literatura, consistente en permeabilizar la c\u00e9lula con una toxina denominada estreptolisina-o para luego proceder a la incubaci\u00f3n con un c\u00f3ctel reprogramador consistente en un extracto proteico de las c\u00e9lulas donante. en este trabajo se ha usado un sistema descrito recientemente en la literatura que aprovecha la ruta transmembrana para introducir prote\u00ednas en el interior celular. Este sistema se<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reprogramacion celular de celulas embrionarias de raton para la obtencion de celulas productoras de insulina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reprogramacion celular de celulas embrionarias de raton para la obtencion de celulas productoras de insulina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miriam Ramirez Dominguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bernat Soria Escoms<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Bedoya bergua <\/li>\n<li>anouchka Skoudy haym (vocal)<\/li>\n<li>Juan Tejedo huaman (vocal)<\/li>\n<li>esther teresa Fuentes marhuenda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miriam Ramirez Dominguez La diabetes es una de las enfermedades cr\u00f3nicas m\u00e1s comunes del mundo, se calcula [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[995,4983,2931,2119,37169],"tags":[126391,11639,90592,117430,126392,126390],"class_list":["post-57209","post","type-post","status-publish","format-standard","hentry","category-desarrollo-animal","category-embriologia-animal","category-enfermedades-de-la-nutricion","category-genetica-animal","category-miguel-hernandez-de-elche","tag-anouchka-skoudy-haym","tag-bernat-soria-escoms","tag-esther-teresa-fuentes-marhuenda","tag-francisco-bedoya-bergua","tag-juan-tejedo-huaman","tag-miriam-ramirez-dominguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/57209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=57209"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/57209\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=57209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=57209"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=57209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}