{"id":57210,"date":"2018-03-09T22:45:02","date_gmt":"2018-03-09T22:45:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-complejo-factor-viia-factor-tisular-y-su-papel-compensatorio-en-las-disfunciones-hemostaticas\/"},"modified":"2018-03-09T22:45:02","modified_gmt":"2018-03-09T22:45:02","slug":"el-complejo-factor-viia-factor-tisular-y-su-papel-compensatorio-en-las-disfunciones-hemostaticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hematologia\/el-complejo-factor-viia-factor-tisular-y-su-papel-compensatorio-en-las-disfunciones-hemostaticas\/","title":{"rendered":"El complejo factor viia-factor tisular y su papel compensatorio en las disfunciones hemost\u00e1ticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raul Tonda Hern\u00e1ndez <\/strong><\/h2>\n<p>Tradicionalmente las terapias de correcci\u00f3n de los defectos hemost\u00e1licos con sustitutivas y se basan en la administraci\u00f3n ex\u00f3gena de derivados sangu\u00edneos o f\u00e1rmacos recombinantes que corrijan la carencia. Pacientes con trombopenia o disfunci\u00f3n planetaria reciben transfusi\u00f3n de concentrados de plaquetas; y se administran derivados plasm\u00e1ticos o factores recombinantes cuando existe un d\u00e9ficit cong\u00e9nito o adquirido de factores de la coagulaci\u00f3n que comprometa la correcta hemostasia. Los estudios realizados en esta tesis han sido dirigidos a investigar sistemas alternativos, a trav\u00e9s del complejo ft\/fviia, como compensatorios de otros elementos hemost\u00e1licos deficitarios. Esta tesis doctoral ha explorado la posibilidad de que potenciar un mecanismo no deficitario, como puede ser la coagulaci\u00f3n iniciada por el complejo ft\/fviia, pueda restablecer una correcta hemostasia tanto en pacientes que presenten coagulopat\u00edas como en pacientes que presenten un d\u00e9ficit en la hemosasia primaria.     para estudiar distintos des\u00f3rdenes hemost\u00e1ticos con sintomatolog\u00eda cl\u00ednica se han empleado aproximaciones experimentales in vitro en sistemas que emulan las condiciones fisiol\u00f3gicas que se encuentran en distintos puntos del \u00e1rbol vascular. Estas metodolog\u00edas permiten estudiar, de una forma no invasiva, los mecanismos implicados en la hemostasia sin exponer a los pacientes a tratamientos agresivos o dosis excesivas. Hemos empleado muestras se sangre procedentes de pacientes con trastornos hemost\u00e1ticos: coagulopat\u00edas, trombocitopat\u00edas y trombocitopenias. entre las coagulopat\u00edas estudiadas se encuentran la hemofilia a, la cirrosis y la anticoagulaci\u00f3n inducida por acenocumarol. Como trombocitopa\u00edtas se han estudiado el s\u00edndrome de bernard-soulier, la trombastenia de glanzmann y la administraci\u00f3n de abciximab.     el mecanismo por el cual la potenciaci\u00f3n de la v\u00eda del ft-viia produce su efecto hemost\u00e1tico viene mediado por la presencia de ft en la zona<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El complejo factor viia-factor tisular y su papel compensatorio en las disfunciones hemost\u00e1ticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El complejo factor viia-factor tisular y su papel compensatorio en las disfunciones hemost\u00e1ticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raul Tonda Hern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gines Escolar Albaladejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pascual Marco Vera <\/li>\n<li>Jordi Fontucerta Boj (vocal)<\/li>\n<li>Joan Cid Vidal (vocal)<\/li>\n<li>LLuis Puig (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raul Tonda Hern\u00e1ndez Tradicionalmente las terapias de correcci\u00f3n de los defectos hemost\u00e1licos con sustitutivas y se basan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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