{"id":57268,"date":"2018-03-09T22:45:05","date_gmt":"2018-03-09T22:45:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-de-induccion-de-apoptosis-por-acadesina-pk11195-y-2-metoxiestradiol-en-la-leucemia-linfoca%c2%adtica-cronica\/"},"modified":"2018-03-09T22:45:05","modified_gmt":"2018-03-09T22:45:05","slug":"mecanismos-moleculares-de-induccion-de-apoptosis-por-acadesina-pk11195-y-2-metoxiestradiol-en-la-leucemia-linfoca%c2%adtica-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/mecanismos-moleculares-de-induccion-de-apoptosis-por-acadesina-pk11195-y-2-metoxiestradiol-en-la-leucemia-linfoca%c2%adtica-cronica\/","title":{"rendered":"Mecanismos moleculares de inducci\u00f3n de apoptosis por acadesina, pk11195 y 2-metoxiestradiol en la leucemia linfoc\u00edtica cr\u00f3nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Fern\u00e1ndez Santidri\u00e1n <\/strong><\/h2>\n<p>En la tesis doctoral se ha estudiado los mecanismos de inducci\u00f3n de drogas que afectan directamente a la mitocondria, como es el caso de 2-metoxiestradiol y pk11195 en la leucemia linfoc\u00edticacr\u00f3nica. Adem\u00e1s se ha estudiado el mecanismo de inducci\u00f3n de apoptosis por acadesina en la leucemia linfoc\u00edtica cr\u00f3nica, as\u00ed como se ha analizado los efectos de acadesina sobre la linfocitosis in vivo en ratones balb\/c.     durante el trabajo desarrollado hemos mostrado que 2-me induce apoptosis a trav\u00e9s de un mecanismos en el que podr\u00eda estar implicado vdac o canales de cloro mitocondriales. Sin embargo, las c\u00e9lulas b normales son iguales de sensibles que las c\u00e9lulas de llc.2-me induce los genes noxa y puma. Un efecto interesante es la observaci\u00f3n que el ruthenium red (rur), un inhibidor de canales de calcio unidireccionales de la mitocondria, sensibiliza de forma clara a la c\u00e9lulas de llc a dosis muy bajas de 2-me. A ra\u00edz de los estudios con 2-me, nos planteamos analizar el efecto de otras drogas de acci\u00f3n mitocondrial que tuvieran como diana alguna de las prote\u00ednas que forman el ptpc, para analizar el efecto de la alteraci\u00f3n de este grupo de prote\u00ednas en la apoptosis de las c\u00e9lulas de llc. Pbr es una prote\u00edna que se encuentra sobreexpresada en la llc. Observamos que pk11195, un ligando de pbr, induce apoptosis en las c\u00e9lulas b de llc y tambi\u00e9n en los linfocitos b de donantes sanos, mientras que los linfocitos t son m\u00e1s resistentes. sin embargo, actualmente, la diana propaopt\u00f3tica de pk11195 no est\u00e1 clara y la participaci\u00f3n de pbr  es controvertida. Es la primera vez que se describe que pk11195 induce apoptosis, y no s\u00f3lo sensibilizaci\u00f3n, en c\u00e9lulas leuc\u00e9micas primarias. Adem\u00e1s, el estudio del mecanismo nos ha mostrado que pk11195 induce apoptosis de forma independiente de p53, dato de inter\u00e9s para su posible uso en pacientes refractorios a la quimioterapia  actual.     el objetivo principal de la tesis fue estudiar el mecanismos de inducc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares de inducci\u00f3n de apoptosis por acadesina, pk11195 y 2-metoxiestradiol en la leucemia linfoc\u00edtica cr\u00f3nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares de inducci\u00f3n de apoptosis por acadesina, pk11195 y 2-metoxiestradiol en la leucemia linfoc\u00edtica cr\u00f3nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Fern\u00e1ndez Santidri\u00e1n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/02\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Gil Santano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mar\u00ed\u00a7al Pastor anglada <\/li>\n<li>cristina Mu\u00f1oz pinedo (vocal)<\/li>\n<li>Luis Ruiz \u00e1vila (vocal)<\/li>\n<li>esther Casta\u00f1o bold\u00fa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Fern\u00e1ndez Santidri\u00e1n En la tesis doctoral se ha estudiado los mecanismos de inducci\u00f3n de drogas que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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