{"id":57416,"date":"2007-09-03T00:00:00","date_gmt":"2007-09-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-regulacion-de-los-genes-de-biosa%c2%adntesis-de-penicilina-por-el-factor-transcripcional-crea-en-penicillium-chrysogenum\/"},"modified":"2007-09-03T00:00:00","modified_gmt":"2007-09-03T00:00:00","slug":"estudio-de-la-regulacion-de-los-genes-de-biosa%c2%adntesis-de-penicilina-por-el-factor-transcripcional-crea-en-penicillium-chrysogenum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/metabolismo-microbiano\/estudio-de-la-regulacion-de-los-genes-de-biosa%c2%adntesis-de-penicilina-por-el-factor-transcripcional-crea-en-penicillium-chrysogenum\/","title":{"rendered":"Estudio de la regulaci\u00f3n de los genes de bios\u00edntesis de penicilina por el factor transcripcional crea en penicillium chrysogenum."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Cepeda Garc\u00eda <\/strong><\/h2>\n<p>La producci\u00f3n de penicilina en p. Chrysogenum est\u00e1 sometida a regulaci\u00f3n por fuente de carbono. El factor transcripcional crea es el responsable de este tipo de regulaci\u00f3n de diversos genes pero hasta ahora no se hab\u00eda demostrado su implicaci\u00f3n en la regulaci\u00f3n por carbono de la ruta de bios\u00edntesis de penicilina en este hongo. Este es el objetivo de la presente tesis. se ha demostrado que la caja crea-1 presente en el promotor del gen pcbab, que codifica la enzima responsable del primer paso de la ruta biosint\u00e9tica de penicilina en p. Chrysogenum, participa en la regulaci\u00f3n por carbono de dicho gen, ya que la mutaci\u00f3n de esta caja provoca un aumento en la expresi\u00f3n del gen pcbab en medios suplementados con glucosa. la mutaci\u00f3n de las cajas crea-5 y crea-6 demuestra que, aunque son funcionales y participan en la regulaci\u00f3n por fuente de carbono del gen pcbab, su importancia no es comparable a la de la caja crea-1. por otro lado, se estudio la propia prote\u00edna crea para ver su implicaci\u00f3n en la producci\u00f3n de penicilina. la deleci\u00f3n del gen crea result\u00f3 en un fenotipo extremo, donde se encuentran seriamente alterados tanto el correcto desarrollo del micelio como la producci\u00f3n de penicilina. mediante la expresi\u00f3n de arn antisentido se determin\u00f3 que la atenuaci\u00f3n del gen crea resulta en una mayor producci\u00f3n de penicilina, independientemente de la fuente de carbono presente en el medio, y este aumento va acompa\u00f1ado por una mayor expresi\u00f3n de los genes pcbab y pcbc. por \u00faltimo, la sobreexpresi\u00f3n del gen crea result\u00f3 en una reducci\u00f3n dr\u00e1stica de la producci\u00f3n de penicilina, lo que apoya los datos anteriores y confirma que el factor crea es el responsable de la regulaci\u00f3n por fuente de carbono de la ruta de bios\u00edntesis de pencilina en p. Chrysogenum.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la regulaci\u00f3n de los genes de bios\u00edntesis de penicilina por el factor transcripcional crea en penicillium chrysogenum.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la regulaci\u00f3n de los genes de bios\u00edntesis de penicilina por el factor transcripcional crea en penicillium chrysogenum. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Cepeda Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Mart\u00edn Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Laborda rodriguez <\/li>\n<li>margarita Orejas su\u00e1rez (vocal)<\/li>\n<li>M\u00aa dolores Arriaga giner (vocal)<\/li>\n<li>Jos\u00e9 Luis Barredo fuente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Cepeda Garc\u00eda La producci\u00f3n de penicilina en p. Chrysogenum est\u00e1 sometida a regulaci\u00f3n por fuente de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,36606,4430,978,1654],"tags":[126855,9645,46076,4494,40173,25943],"class_list":["post-57416","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-biologia-molecular-de-microorganismos","category-leon","category-metabolismo-microbiano","category-micologia","tag-cristina-cepeda-garcia","tag-fernando-laborda-rodriguez","tag-jose-luis-barredo-fuente","tag-juan-francisco-martin-martin","tag-margarita-orejas-suarez","tag-ma-dolores-arriaga-giner"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/57416","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=57416"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/57416\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=57416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=57416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=57416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}