{"id":57420,"date":"2007-09-03T00:00:00","date_gmt":"2007-09-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-inmunoqua%c2%admico-y-funcional-de-la-variabilidad-de-las-cadenas-cd3-epsilon-del-complejo-tcr-cd3\/"},"modified":"2007-09-03T00:00:00","modified_gmt":"2007-09-03T00:00:00","slug":"analisis-inmunoqua%c2%admico-y-funcional-de-la-variabilidad-de-las-cadenas-cd3-epsilon-del-complejo-tcr-cd3","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-inmunoqua%c2%admico-y-funcional-de-la-variabilidad-de-las-cadenas-cd3-epsilon-del-complejo-tcr-cd3\/","title":{"rendered":"An\u00e1lisis inmunoqu\u00edmico y funcional de la variabilidad de las cadenas cd3 epsilon del complejo tcr\/cd3"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Bello Collantes <\/strong><\/h2>\n<p>Los datos actuales del receptor de ant\u00edgeno del linfocito t (complejo tcr\/cd3) han sido obtenidos utilizando diversos tipos de c\u00e9lulas o l\u00edneas celulares y meditan diferentes aproximaciones experimentales, y ser\u00eda razonable concluir que el complejo tcr\/cd3 es una estructura constante cuyos componentes, exceptuando las regiones variables del tcr. Son iguales en todos los linfocitos t. Por el contrario, hab\u00edamos detectado previamente diferencias en la secuencia amino-terminal de cd3 epsilon y con interacciones tcr-cd3 m\u00e1s d\u00e9biles.     en esta tesis mostramos que los complejos tcr\/cd3 de la superficie de los linfocitos t de rat\u00f3n y de diferentes l\u00edneas celulares expresan distintas cadenas de cd3 epsilon con distinto punto isoel\u00e9ctrico, que se corresponden con los puntos isoel\u00e9ctricos te\u00f3ricos de cadenas que han perdido uno o dos residuos cargados negativamente del extremoamino-terminal de esta prote\u00edna.     asimismo, diferentes l\u00edneas celulares presentan distinta proporci\u00f3n de isoformas de cd3 epsilon, correlacion\u00e1ndose la avidez de la uni\u00f3n del anticuerpo ycd3.1 con la abundancia de cadenas de punto isoel\u00e9ctrico alto. Por otra parte, hemos observado la existencia de complejos tcr\/cd3 mono y multivalentes en estas l\u00edneas celulares, siendo mayor la proporci\u00f3n de cadenas completas en los complejos monovalentes. nuestros datos indican tambi\u00e9n que los residuos \u00e1cidos del extremo amino-terminal de cd3 epsilon est\u00e1n implicados en la interacci\u00f3n con el tcr, y que existen distintas proteasas implicadas en el proceso de degradaci\u00f3n de esta prote\u00edna. As\u00ed utilizando un inhibidor de metaloproteasas hemos observado una disminuci\u00f3n en la degradaci\u00f3n de cd3 epsilon y por el contrario, utilizando un inhibidor de aminopeptidasas hemos observado un aumento de la degradaci\u00f3n.     la existencia de distintas cadenas de cd3 epsilon da lugar a diferentes consecuencias funcionales. Por un lado existen diferencias en la estructura de los complejos trc\/d3, d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis inmunoqu\u00edmico y funcional de la variabilidad de las cadenas cd3 epsilon del complejo tcr\/cd3<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis inmunoqu\u00edmico y funcional de la variabilidad de las cadenas cd3 epsilon del complejo tcr\/cd3 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Bello Collantes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Rojo Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Martin villa <\/li>\n<li>Mar\u00eda Botella Luisa (vocal)<\/li>\n<li>balbino Jos\u00e9 Alarcon sanchez (vocal)<\/li>\n<li>tilman S\u00e1nchez-elsner (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Bello Collantes Los datos actuales del receptor de ant\u00edgeno del linfocito t (complejo tcr\/cd3) han sido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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