{"id":57459,"date":"2007-10-03T00:00:00","date_gmt":"2007-10-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-inhbicion-genetica-y-farmacologica-de-la-actividad-poli-adp-ribosa-polimerasa-en-la-pancreatitis-aguda-experimental\/"},"modified":"2007-10-03T00:00:00","modified_gmt":"2007-10-03T00:00:00","slug":"efecto-de-la-inhbicion-genetica-y-farmacologica-de-la-actividad-poli-adp-ribosa-polimerasa-en-la-pancreatitis-aguda-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-de-trasplantes\/efecto-de-la-inhbicion-genetica-y-farmacologica-de-la-actividad-poli-adp-ribosa-polimerasa-en-la-pancreatitis-aguda-experimental\/","title":{"rendered":"Efecto de la inhbici\u00f3n gen\u00e9tica y farmacol\u00f3gica de la actividad poli-adp-ribosa polimerasa en la pancreatitis aguda experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rub\u00e9n Avelino Mota Blanco <\/strong><\/h2>\n<p>La pancreatitis aguda (pa) consiste en una inflamaci\u00f3n aguda del p\u00e1ncreas producida, generalmente, por una litiasis biliar. En el 75-80% de los casos la evoluci\u00f3n cl\u00ednica es benigna ya que responde a la terap\u00e9utica m\u00e9dica. Sin embargo, en un 20-25% de los casos la evoluci\u00f3n es grave, apareciendo complicaciones sist\u00e9micas y\/o locales (necrosis pancre\u00e1tica, abscesos, etc.) Que ocasionan la muerte, en un 30-40% de los pacientes, a consecuencia de un s\u00edndrome de respuesta inflamatoria sist\u00e9mica que determina un fracaso multiorg\u00e1nico. Principalmente, el pulm\u00f3n y el h\u00edgado son los \u00f3rganos m\u00e1s afectados y los mediadores inflamatorios m\u00e1s frecuentemente involucrados son la interleuquina (il)-1 , el factor de necrosis tumoral ? (Tnf- ), la il-6, la il-8 y el factor de activaci\u00f3n plaquetaria (paf).  en la actualidad, la investigaci\u00f3n experimental intenta conocer la fisiopatolog\u00eda de la pa con el fin de predecir los casos severos y b\u00fasqueda de nuevas dianas terap\u00e9uticas. En este sentido, los modelos animales, especialmente los ratones por la facilidad que presentan para la inactivaci\u00f3n espec\u00edfica de genes, est\u00e1 contribuyendo a un mejor conocimiento de los mecanismos intr\u00ednsecos de la pa. Recientemente, se ha sugerido que la enzima nuclear poli-adp-ribosa polimerasa-1 (parp-1) est\u00e1 directamente implicada en inflamaci\u00f3n sist\u00e9mica. Parp-1 es una enzima nuclear que se activa en respuesta a roturas en el dna generadas por diferentes agentes genot\u00f3xicos y, utilizando nad+ como sustrato, sintetiza y transfiere adp-ribosa a otras prote\u00ednas nucleares, incluida ella misma. Parp-1 esta involucrada en procesos de reparaci\u00f3n del dna, proliferaci\u00f3n-diferenciaci\u00f3n celular, apoptosis, as\u00ed como en la regulaci\u00f3n de la transcripci\u00f3n. una hip\u00f3tesis con respecto a la implicaci\u00f3n de parp-1 en la inflamaci\u00f3n es que los est\u00edmulos proinflamatorios inducen la producci\u00f3n de radicales libres de ox\u00edgeno y \u00f3xido n\u00edtrico, con la formaci\u00f3n posterior de peroxini<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la inhbici\u00f3n gen\u00e9tica y farmacol\u00f3gica de la actividad poli-adp-ribosa polimerasa en la pancreatitis aguda experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la inhbici\u00f3n gen\u00e9tica y farmacol\u00f3gica de la actividad poli-adp-ribosa polimerasa en la pancreatitis aguda experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rub\u00e9n Avelino Mota Blanco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Yelamos Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pascual Parrilla <\/li>\n<li>pedro Aparicio (vocal)<\/li>\n<li>david Hern\u00e1ndez (vocal)<\/li>\n<li>ignacio Landa jose (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rub\u00e9n Avelino Mota Blanco La pancreatitis aguda (pa) consiste en una inflamaci\u00f3n aguda del p\u00e1ncreas producida, generalmente, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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