{"id":57529,"date":"2018-03-09T22:45:19","date_gmt":"2018-03-09T22:45:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismo-fok-i-del-receptor-de-vitamina-d-y-recambio-oseo-en-pacientes-con-ortodoncia\/"},"modified":"2018-03-09T22:45:19","modified_gmt":"2018-03-09T22:45:19","slug":"polimorfismo-fok-i-del-receptor-de-vitamina-d-y-recambio-oseo-en-pacientes-con-ortodoncia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismo-fok-i-del-receptor-de-vitamina-d-y-recambio-oseo-en-pacientes-con-ortodoncia\/","title":{"rendered":"Polimorfismo fok i del receptor de vitamina d y recambio \u00f3seo en pacientes con ortodoncia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Cerdeira Gregorio <\/strong><\/h2>\n<p>Durante el movimiento ortod\u00f3ntico existe susceptibilidad de p\u00e9rdida \u00f3sea, que puede comprometer la longevidad de la pieza dentaria. La vitamina d y la hormona paratiroidea (pth) son dos hormonas que participan en la regulaci\u00f3n del metabolismo mineral \u00f3seo y en la homeostasis del calcio. La 1,25 dihidroxivitamina d3, metabolito m\u00e1s activo de la vitamina d, interviene de forma activa en el proceso de remodelado \u00f3seo que tiene lugar durante el movimiento ortod\u00f3ntico, a trav\u00e9s de la uni\u00f3n a su receptor, vdr. As\u00ed, la vitamina d estimula la resorci\u00f3n \u00f3sea a trav\u00e9s de una acci\u00f3n primaria sobre los osteoblastos que se ven inducidos por la hormona a producir otros factores paracrinos que estimulan a los osteoclastos, los cuales a su vez comienzan a reabsorber hueso. El gen de vdr contiene dos posibles codones de inicio (atg) de la transcripci\u00f3n en el ex\u00f3n ii. En el primer cod\u00f3n atg, se ha detectado un polimorfismo usando el enzima de restricci\u00f3n fok i. Consiste en una mutaci\u00f3n puntual de t por c, atg pasa a acg, de modo que se produce un desplazamiento de la transcripci\u00f3n al segundo cod\u00f3n de inicio, localizado tres codones m\u00e1s abajo. Esta mutaci\u00f3n da lugar a una prote\u00edna tres amino\u00e1cidos m\u00e1s corta, de modo que se ven alteradas sus funciones, como la de regulaci\u00f3n de la expresi\u00f3n de genes implicados en la remodelaci\u00f3n \u00f3sea, asoci\u00e1ndose esta mutaci\u00f3n, en algunas poblaciones, con una mayor densidad mineral \u00f3sea. el objetivo de este trabajo ha sido establecer la posible relaci\u00f3n entre el polimorfismo fok i de vdr y el recambio \u00f3seo generado en pacientes ortod\u00f3nticos.   a partir de una muestra de sangre perif\u00e9rica de cada paciente se obtuvo adn gen\u00f3mico utilizando el m\u00e9todo de extracci\u00f3n del fenol-cloroformo, y a continuaci\u00f3n se amplific\u00f3 por pcr un fragmento del receptor de vdr de 265 pb. Despu\u00e9s, se procedi\u00f3 a la identificaci\u00f3n de los diferentes genotipos, ff\/ff\/ff, mediante corte enzim\u00e1tico con fok i, siendo f el alelo normal y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismo fok i del receptor de vitamina d y recambio \u00f3seo en pacientes con ortodoncia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismo fok i del receptor de vitamina d y recambio \u00f3seo en pacientes con ortodoncia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Cerdeira Gregorio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Carmen Segura Iglesias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Suarez quintanilla <\/li>\n<li>eva Vigo gago (vocal)<\/li>\n<li>eduardo Bratos calvo (vocal)<\/li>\n<li>Javier Fernandez feijoo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Cerdeira Gregorio Durante el movimiento ortod\u00f3ntico existe susceptibilidad de p\u00e9rdida \u00f3sea, que puede comprometer la longevidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[467,9,977],"tags":[36334,127110,127108,66422,35029,127109],"class_list":["post-57529","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-nutricion","category-ciencias-medicas","category-santiago-de-compostela","tag-eduardo-bratos-calvo","tag-eva-vigo-gago","tag-francisco-cerdeira-gregorio","tag-javier-fernandez-feijoo","tag-juan-antonio-suarez-quintanilla","tag-maria-del-carmen-segura-iglesias"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/57529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=57529"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/57529\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=57529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=57529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=57529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}