{"id":57545,"date":"2018-03-09T22:45:19","date_gmt":"2018-03-09T22:45:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-adn-polimerasa-lambda-humana-en-reparacion-de-dano-oxidativo-y-roturas-de-doble-cadena-en-el-adn\/"},"modified":"2018-03-09T22:45:19","modified_gmt":"2018-03-09T22:45:19","slug":"papel-de-la-adn-polimerasa-lambda-humana-en-reparacion-de-dano-oxidativo-y-roturas-de-doble-cadena-en-el-adn","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/enzimologia\/papel-de-la-adn-polimerasa-lambda-humana-en-reparacion-de-dano-oxidativo-y-roturas-de-doble-cadena-en-el-adn\/","title":{"rendered":"Papel de la adn polimerasa lambda humana en reparaci\u00f3n de da\u00f1o oxidativo y roturas de doble cadena en el adn"},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00e1ngel Joaquin Picher Serantes <\/strong><\/h2>\n<p>Pol lambda, un miembro recientemente descrito de la familia x de adn polimerasa, es estudiado en esta tesis doctoral. Este enzima muestra un 32% de identidad de secuencia con  pol beta, que participa en la reparaci\u00f3n del adn nuclear en c\u00e9lulas eucari\u00f3ticas. Estudios previos revelaron que pol lambda posee actividad polimerasa y drp-liasa, de forma consistente con un posible papel en la reparaci\u00f3n por escisi\u00f3n de base. Al contrario que pol beta, pol lambda posee en su regi\u00f3n n-terminal un dominio brct y una regi\u00f3n rica en amino\u00e1cidos serina, prolina y treonina. Pol lambda es una enzima distributivo y dependiente de cadena molde, que carece de actividad correctora de errores y que muestra una gran afinidad por dntps.     en este trabajo hemos realizado estudios que sugieren un papel de pol lambda en la reparaci\u00f3n por escisi\u00f3n de base in vivo. La evaluaci\u00f3n de la capacidad de reparaci\u00f3n de extractos celulares totales derivados de diferentes tejidos y fibroblastos embrionarios procedentes del modelo murino deficiente en pol lambad, as\u00ed como de una l\u00ednea celular que sobre-expresa pol lambda, sugiere un papel de esta polimerasa en la reparaci\u00f3n por escisi\u00f3n de base en cerebro y durante el desarrollo post-natal de test\u00edculo. Adem\u00e1s, la sobre-expresi\u00f3n de pol lambda produce un incremento en la capacidad global de reparaci\u00f3n.     la regulaci\u00f3n post-traduccional de la actividad drp-liasa de pol beta ha sido previamente demostrada. Pol beta se acetila por p300, lo que provoca la inhibici\u00f3n espec\u00edfica de su actividad drp-liasa. En este trabajo hemos demostrado que pol lambda tambi\u00e9n se acetila por p300, aunque este proceso no inhibe su actividad drp-liasa, lo que sugiere que la acetilaci\u00f3n sea un mecanismo de regulaci\u00f3n diferencial de ambas polimerasas durante la ruta de reparaci\u00f3n por escisi\u00f3n de base.     para evaluar la implicaci\u00f3n de pol lambda en diferentes procesos de reparaci\u00f3n, hemos realizado un estudio de afinidad de uni\u00f3n a diferen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la adn polimerasa lambda humana en reparaci\u00f3n de da\u00f1o oxidativo y roturas de doble cadena en el adn<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la adn polimerasa lambda humana en reparaci\u00f3n de da\u00f1o oxidativo y roturas de doble cadena en el adn <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00e1ngel Joaquin Picher Serantes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Blanco D\u00e1vila<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fernandez piqueras <\/li>\n<li>Ana Bonnin bioslada (vocal)<\/li>\n<li>vicente Larraga (vocal)<\/li>\n<li> Vega Jos\u00e9 Miguel de (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00e1ngel Joaquin Picher Serantes Pol lambda, un miembro recientemente descrito de la familia x de adn polimerasa, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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