{"id":5755,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/investigacion-sobre-farmacos-n-derivados-de-uracilos-5-sustituidos\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"investigacion-sobre-farmacos-n-derivados-de-uracilos-5-sustituidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/investigacion-sobre-farmacos-n-derivados-de-uracilos-5-sustituidos\/","title":{"rendered":"Investigacion sobre farmacos n derivados de uracilos 5-sustituidos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pineda De Las Infantas Villatoro M. Jose <\/strong><\/h2>\n<p>En la presente memoria se afronta la sintesis, caracterizacion, evaluacion biologica y estudios conformacionales de una serie de nucleosidos pirimidinicos derivados de vacilos 5-sustituidos. Se han ensayado dos rutas sinteticas para la sintesis de nuestro aciclonucleosidos, y la que nos ha conducido a mejores rendimientos es por apertura regio especifica de cicloacetales heptagonales.  se ha evaluado la actividad biologica de estos compuestos siendo el mas activo el 3-(2-hidroxietoxi) -1- isopropoxi-1- (fluoro-1-uracil)- propano siendo dos veces mas activo que el propio 5-fluorouracilo.  mediante estudios de modelizacion molecular se ha observado que estas estructuras no mimetizan al nucleosido natural desoxiuridina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Investigacion sobre farmacos n derivados de uracilos 5-sustituidos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Investigacion sobre farmacos n derivados de uracilos 5-sustituidos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pineda De Las Infantas Villatoro M. Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Espinosa \u00fabeda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Melgarejo Sampedro <\/li>\n<li>Miguel Fernandez Bra\u00f1a (vocal)<\/li>\n<li>Enrique Ravi\u00f1a Rubira (vocal)<\/li>\n<li> Orte Martinez Juan  Carlos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pineda De Las Infantas Villatoro M. Jose En la presente memoria se afronta la sintesis, caracterizacion, evaluacion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,902,17,416],"tags":[3852,2578,6660,22281,3992,22280],"class_list":["post-5755","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-estereoquimica-y-analisis-conformacional","category-quimica","category-quimica-organica","tag-antonio-espinosa-ubeda","tag-enrique-ravina-rubira","tag-miguel-fernandez-brana","tag-miguel-melgarejo-sampedro","tag-orte-Martinez-juan-carlos","tag-pineda-de-las-infantas-villatoro-m-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/5755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=5755"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/5755\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=5755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=5755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=5755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}