{"id":57554,"date":"2018-03-09T22:45:19","date_gmt":"2018-03-09T22:45:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-inmunogenicidad-de-candidatos-a-vacuna-contra-la-leishmaniasis-visceral-en-el-modelo-canino-de-infeccion-experimental\/"},"modified":"2018-03-09T22:45:19","modified_gmt":"2018-03-09T22:45:19","slug":"estudio-de-la-inmunogenicidad-de-candidatos-a-vacuna-contra-la-leishmaniasis-visceral-en-el-modelo-canino-de-infeccion-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-inmunogenicidad-de-candidatos-a-vacuna-contra-la-leishmaniasis-visceral-en-el-modelo-canino-de-infeccion-experimental\/","title":{"rendered":"Estudio de la inmunogenicidad de candidatos a vacuna contra la leishmaniasis visceral en el modelo canino de infecci\u00f3n experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eugenia Carrillo Gallego <\/strong><\/h2>\n<p>La infecci\u00f3n experimental con leishmania infantum realizada en este trabajo fue capaz de producir una respuesta celular espec\u00edfica frente la par\u00e1sito patente en animales asintom\u00e1ticos y oligosintom\u00e1ticos en la fase cr\u00f3nica de la infecci\u00f3n. La respuesta celular espec\u00edfica gerente a leishmania y la cuantificaci\u00f3n del patr\u00f3n de expresi\u00f3n de citoquinas por rt-pcr a tiempo real en los animales infectados de manera experimental con l.Infantum estuvieron relacionados con el estado cl\u00ednico que desarrollaron los perros. la respuesta inmune de los perros asintom\u00e1ticos y oligosintom\u00e1ticos frente al par\u00e1sito se caracteriz\u00f3 por la dominancia de la expresi\u00f3n de citoquinas de tipo th1 (ifn-gamma, tnf-alfa) que no excluy\u00f3 la expresi\u00f3n simult\u00e1nea de citoquinas th2 (il-4,il-10). Los animales polisintom\u00e1ticos no mostraron respuesta celular espec\u00edfica ni cambios en la expresi\u00f3n de las citoquinas estudiadas. Adem\u00e1s se encontr\u00f3 una ausencia generalizada de cambios en la expresi\u00f3n de il-18.     los ant\u00edgenos de leishmania spp evaluados empleando el modelo canino, mostraron la presencia de ep\u00edtopos b (hsp70, hsp83, grp94, l25,ndpk, haspb1, kmp-11, kinesia y p-8) y ep\u00edtopos t (hsp70, kmp-11, pfr-2, p-8). No pudimos determinar cambios en la expresi\u00f3n g\u00e9nica de citoquinas tras la estimulaci\u00f3n de pbmcs con los ant\u00edgenos h1 y haspb1. La cualificaci\u00f3n de la expresi\u00f3n de citoquinas inducida por los ant\u00edgenos hsp70, kmp-11, pfr-2 y p-8 mostr\u00f3 una expresi\u00f3n predominante de inf-gamma y tnf-alfa, mostrando el potencial de estos ant\u00edgenos como candidatos a vacuna frente a leishmaniasis visceral canina.     los ensayos de infecic\u00f3n con cepas de l.Infantum aisladas de pacientes inmunodeficientes en la l\u00ednea macrof\u00e1gica\/monoc\u00edtica canina dh82 mostraron una menor capacidad de infecci\u00f3n, una discreta disminuci\u00f3n de la expresi\u00f3n celular de mhc i y un incremento de la expresi\u00f3n de cd80 en comparaci\u00f3n con los ensayos realizados con una cepa infectiva de dem<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la inmunogenicidad de candidatos a vacuna contra la leishmaniasis visceral en el modelo canino de infecci\u00f3n experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la inmunogenicidad de candidatos a vacuna contra la leishmaniasis visceral en el modelo canino de infecci\u00f3n experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eugenia Carrillo Gallego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Alvar Ezquerra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: C\u00e9sar Nombela Cano <\/li>\n<li>Jordi Alberoca Domingo (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Requena Rolan\u00eda (vocal)<\/li>\n<li>Francisco Javier Nieto  Mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eugenia Carrillo Gallego La infecci\u00f3n experimental con leishmania infantum realizada en este trabajo fue capaz de producir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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