{"id":57618,"date":"2018-03-09T22:45:24","date_gmt":"2018-03-09T22:45:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-propofol-sobre-la-vida-del-oxido-na%c2%adtrico-en-condiciones-in-vitro-y-en-pacientes-quirurgicos\/"},"modified":"2018-03-09T22:45:24","modified_gmt":"2018-03-09T22:45:24","slug":"efecto-de-propofol-sobre-la-vida-del-oxido-na%c2%adtrico-en-condiciones-in-vitro-y-en-pacientes-quirurgicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/accion-de-los-farmacos\/efecto-de-propofol-sobre-la-vida-del-oxido-na%c2%adtrico-en-condiciones-in-vitro-y-en-pacientes-quirurgicos\/","title":{"rendered":"Efecto de propofol sobre la vida del \u00f3xido n\u00edtrico en condiciones in vitro y en pacientes quir\u00fargicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esperanza Cruz Andreotti <\/strong><\/h2>\n<p>Objetivos     el objetivo del estudio ha sido analizar el efecto de propofol sobre las actividades sint\u00e9ticas del \u00f3xido n\u00edtrico en leucocitos humanos, tanto en condicen in vitro como en pacientes quir\u00fargicos, y valorar si esta influencia es directa o mediada por mecanismos reguladores end\u00f3genos de la producci\u00f3n de \u00f3xido n\u00edtrico.  metodolog\u00eda     la poblaci\u00f3n de estudio fue doble: voluntarios sanos para obtenci\u00f3n de muestras sangu\u00edneas destinadas a la fase de estuido in vitro, y pacientes quir\u00fargicos para la realizaci\u00f3n del estudio ex vivo. En todos los casos, con consentimiento informado de los pacientes. mediciones: determinaci\u00f3n de nitritos plasm\u00e1ticos, prote\u00ednas, \u00f3xido n\u00edtrico-sintasa, actividad ciclooxigenasa tipos i y ii, procesamiento de enzimoinmunoensayos de txb2, pge2, il1b, il-6, il-10 y tnfalfa.  resultados y conclusiones     propofol estimula la producci\u00f3n basal de \u00f3xido n\u00edtrico mediante la activaci\u00f3n de la \u00f3xido n\u00edtrico sintasa constitutiva y ejerce un efecto inhibitorio de la indecible; la disminuci\u00f3n del a tensi\u00f3n arterial producida por propopol en los pacientes quir\u00fargicos se correlaciona significativamente con los niveles de \u00f3xido n\u00edtrico circulantes, asimismo, propofol inhibe las cilooxigenasas, tanto constitutiva como inducible; la infusi\u00f3n intravenosa de propofol disminuye los niveles de los mediadores proinflamatorios en los pacientes quir\u00fargicos, y ejerce un efecto inhibitorio sobre los mecanismos reguladores delas actividades enzim\u00e1ticas inducibles en los pacientes quir\u00fargicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de propofol sobre la vida del \u00f3xido n\u00edtrico en condiciones in vitro y en pacientes quir\u00fargicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de propofol sobre la vida del \u00f3xido n\u00edtrico en condiciones in vitro y en pacientes quir\u00fargicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esperanza Cruz Andreotti <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro De La Cruz Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Garc\u00eda raimundo <\/li>\n<li> Carmona aurioles Jos\u00e9 Antonio (vocal)<\/li>\n<li>julio Juan G\u00e1lvez peralta (vocal)<\/li>\n<li>Mar\u00eda  monsalud Arrebola ramirez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esperanza Cruz Andreotti Objetivos el objetivo del estudio ha sido analizar el efecto de propofol sobre las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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