{"id":57796,"date":"2018-03-09T22:45:36","date_gmt":"2018-03-09T22:45:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/oxidacion-e-inflamacion-en-la-hiperlipidemia-familiar-combinada\/"},"modified":"2018-03-09T22:45:36","modified_gmt":"2018-03-09T22:45:36","slug":"oxidacion-e-inflamacion-en-la-hiperlipidemia-familiar-combinada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/oxidacion-e-inflamacion-en-la-hiperlipidemia-familiar-combinada\/","title":{"rendered":"Oxidaci\u00f3n e inflamaci\u00f3n en la hiperlipidemia familiar combinada"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Mart\u00ednez Herv\u00e1s <\/strong><\/h2>\n<p>La hfc es una enfermedad muy frecuente, con una preValencia estimada del 1-3% en la poblaci\u00f3n general y hasta del 20% en pacientes con cardiopat\u00eda isqu\u00e9mica precoz. Su base metab\u00f3lica y gen\u00e9tica no ha sido todav\u00eda identificada, siendo el mecanismo m\u00e1s probable la interacci\u00f3n de diferentes genes y el ambiente. Se caracteriza por presentar varios fenotipos lipoproteicos en las misma familia, e incluso en el mismo individuo, a lo largo de su evoluci\u00f3n, generalmente por cambios en los factores ex\u00f3genos. El diagn\u00f3stico se basa en el estudio familiar  y la expresi\u00f3n fenot\u00edpica variable con elevaci\u00f3n de la apo b plasm\u00e1tica. Los mecanismos patog\u00e9nicos implicados en la hfc son muy heterog\u00e9nos y no totalmente conocidos. Se consideran fundametnalmente los siguientes: hiperproducci\u00f3n hep\u00e1tica de vldl, defecto en la actividad de la lipoprotein lipasa, alteraciones en la esterificci\u00f3n de lso \u00e1cidos grasos en el tejido adiposo y la presencia de resistencia a la insulina (ri). Sin embargo, el da\u00f1o org\u00e1nico y el inicio y desarrollo de la enfermedad cardiovascular es heterog\u00e9neo en este grupo de pacientes, lo que indica que necesariamente deben exisitr otros factores de riesgo, adme\u00e1s de la dislipemia, que justifiquen esta variabilidad. Ene ste sentido, dos factores poco estudiados y emergentes son el nivel de estr\u00e9s oxidativo (eo) y la inflamaci\u00f3n.     la hfc es un modelo gen\u00e9tico de hiperlipidemia mixta con ri, alteraci\u00f3n de la lipemia postprandial y aterosclerosis precoz.     en este sentido, la hip\u00f3tesis de trabajo es: \u00aben la hfc debe existir estr\u00e9s oxidativo y activaci\u00f3n de fctores inflamatorios implicados en el inicio y desarrollo de la ae que estar\u00e1n relacionados con el grado de ri y sus determinantes cl\u00ednicos\u00bb.     para evaluar dichas hip\u00f3tesis, se plantaron dos objetivos fundamentales:     1.- Conocer el nivel de eo y factores de inflamaci\u00f3n relacionados con la ae en sujetos con hfc y controles.     2.- Analizar la relaci\u00f3n entr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Oxidaci\u00f3n e inflamaci\u00f3n en la hiperlipidemia familiar combinada<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Oxidaci\u00f3n e inflamaci\u00f3n en la hiperlipidemia familiar combinada <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Mart\u00ednez Herv\u00e1s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  F Ascaso Gimilio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Carmena rodriguez <\/li>\n<li>Jaime Merino sanchez (vocal)<\/li>\n<li>Juan Rubies prat (vocal)<\/li>\n<li> Pedro-botet montoya Juan  Carlos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Mart\u00ednez Herv\u00e1s La hfc es una enfermedad muy frecuente, con una preValencia estimada del 1-3% en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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