{"id":57826,"date":"2018-03-09T22:45:40","date_gmt":"2018-03-09T22:45:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-mecanismos-implicados-en-la-neurodegeneracion-estriatal-en-modelos-murinos-de-la-enfermedad-de-huntington\/"},"modified":"2018-03-09T22:45:40","modified_gmt":"2018-03-09T22:45:40","slug":"estudio-de-los-mecanismos-implicados-en-la-neurodegeneracion-estriatal-en-modelos-murinos-de-la-enfermedad-de-huntington","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/estudio-de-los-mecanismos-implicados-en-la-neurodegeneracion-estriatal-en-modelos-murinos-de-la-enfermedad-de-huntington\/","title":{"rendered":"Estudio de los mecanismos implicados en la neurodegeneraci\u00f3n estriatal en modelos murinos de la enfermedad de huntington"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Torres Peraza Jes\u00fas Fernando <\/strong><\/h2>\n<p>Esta memoria, ha perseguido determinar la implicaci\u00f3n de las neurotrofinas end\u00f3genas bdnf y la nt-3 en la susceptibilidad de las neuronas estriatales en modelos transg\u00e9nicos y excitot\u00f3ticos de la enfermedad de huntington, estudiar la implicaci\u00f3n de los agregados intraneuronales y de la excitotoxicidad mediada por los receptores nmda en modelos transg\u00e9nicos de la enfermedad de huntington y analizar el potencial de dos aproximaciones terap\u00e9uticas para la enfermedad de huntington basadas en la administraci\u00f3n de bdnf intra-estriatal o en el silenciamiento del gen causante de la patolog\u00eda.  en dicha memoria se han empleado modelos murinos de la enfermedad de huntington, el modelo excitot\u00f3xico y diversos modelos transg\u00e9nicos con alteraciones espec\u00edficas de los niveles de bdnf o la nt-3, ratones condicionales de la huntingtina mutada, as\u00ed como tambi\u00e9n cultivos primarios y de precursores neuronales estriatales. los resultados se han presentado como 3 art\u00edculos cient\u00edficos originales publicados en revistas indexadas (the journal of neurosciencie y neurosciencie) y un art\u00edculo original en fase de preparaci\u00f3n.  adem\u00e1s, se ha realizado una discusi\u00f3n conjunta de los resultados presentados en los diferentes art\u00edculos cient\u00edficos cumpliendo completamente con los objetivos planteados. En conjunto, los resultados aportan datos relevantes que ayudan a entender la fisiopatolog\u00eda de la enfermedad de huntington y la fisiolog\u00eda delas neuronas estriatales. en esta tesis se ha determinado que la disminuci\u00f3n de los niveles de neutrofinas afecta diferencialmente la susceptibilidad de las neuronas estriatales en modelos murinos y excitot\u00f3xicos de la enfermedad de huntington. As\u00ed el bdnf es el factor que modula el inicio y la severidad de las alteraciones motoras asociados a la degeneraci\u00f3n selectiva de las neuronas estriatales de proyecci\u00f3n en el modelo transg\u00e9nico r6\/1. Por su parte es la nt-3 el factor neurort\u00f3fco que modula la susceptibilidad exictot\u00f3xic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los mecanismos implicados en la neurodegeneraci\u00f3n estriatal en modelos murinos de la enfermedad de huntington<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los mecanismos implicados en la neurodegeneraci\u00f3n estriatal en modelos murinos de la enfermedad de huntington <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Torres Peraza Jes\u00fas Fernando <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Alberch I Vie<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Josep Esquerda <\/li>\n<li>Isabel P\u00e9rez Ota\u00f1o (vocal)<\/li>\n<li>Ram\u00f3n Trullas (vocal)<\/li>\n<li>Angel Luis Barco Guerrero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Torres Peraza Jes\u00fas Fernando Esta memoria, ha perseguido determinar la implicaci\u00f3n de las neurotrofinas end\u00f3genas bdnf y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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