{"id":57914,"date":"2018-03-09T22:45:43","date_gmt":"2018-03-09T22:45:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-sustratos-y-inhibidores-de-la-ssao-vap-1\/"},"modified":"2018-03-09T22:45:43","modified_gmt":"2018-03-09T22:45:43","slug":"sa%c2%adntesis-de-sustratos-y-inhibidores-de-la-ssao-vap-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/sa%c2%adntesis-de-sustratos-y-inhibidores-de-la-ssao-vap-1\/","title":{"rendered":"S\u00edntesis de sustratos y inhibidores de la ssao\/vap-1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francesc Yraola Font <\/strong><\/h2>\n<p>Esta tesis doctoral se ha centrado en el dise\u00f1o, la s\u00edntesis y la evaluaci\u00f3n biol\u00f3gica de sustratos y inhibidores de la enzima ssao\/vap-1.     en el caso de los sustratos de la ssao\/vap-1, el objetivo fundamental ha sido el desarrollo de nuevos compuestos capaces de interaccionar eficientemente con el centro activo dela enzima encontr\u00e1ndose que distintos tipos de arilalquilaminas pueden actuar como potentes sustratos de la ssao\/vap-1. Entre todos los compuestos evaluados, se han encontrado 4 que son excelentes sustratos ssao\/vap-1 humana y se han identificado un conjunto de relaciones de estructura-actividad relevantes para futuros dise\u00f1os.     por otro lado, en estudios previos se hab\u00eda demostrado que la combinaci\u00f3n de estos sustratos con vanadio tienen potentes efectos antidiab\u00e9ticos. Por ello, se han preparado un conjunto de sales de vanadio con los nuevos sustratos de la ssao identificados en esta tesis doctoral. Estas sales han demostrado tener potentes efectos diab\u00e9ticos i antidislip\u00e9micos son suficientes novedad para su patentabilidad.     en el caso delos inhibidores, sehan dise\u00f1ado y sintetizado en fase s\u00f3lida un conjunto de mol\u00e9culas que son capaces de inhibir selectivamente la actividad amino-oxidasa de la ssao\/vap-1, detect\u00e1ndose una familia de compuestos que tienen mol\u00e9culas con propiedades pr\u00f3ximas a ser considerados hits para el posterior desarrollo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de sustratos y inhibidores de la ssao\/vap-1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de sustratos y inhibidores de la ssao\/vap-1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francesc Yraola Font <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Albericio Palomera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ernest Giralt lledo <\/li>\n<li>Fernando P. cossio (vocal)<\/li>\n<li>Antonio Zorzano olarte (vocal)<\/li>\n<li>angel Massaguer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francesc Yraola Font Esta tesis doctoral se ha centrado en el dise\u00f1o, la s\u00edntesis y la evaluaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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