{"id":57918,"date":"2018-03-09T22:45:43","date_gmt":"2018-03-09T22:45:43","guid":{"rendered":""},"modified":"2018-03-09T22:45:43","modified_gmt":"2018-03-09T22:45:43","slug":"sa%c2%adntesis-y-evaluacion-biologica-de-inhibidores-pepta%c2%addicos-de-la-beta-secretasa-y-de-nuevos-derivados-de-nitroazucares-benzocarbazoldionas-polihidroxiladas-beta-aminoacidos-cicloalcanicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/sa%c2%adntesis-y-evaluacion-biologica-de-inhibidores-pepta%c2%addicos-de-la-beta-secretasa-y-de-nuevos-derivados-de-nitroazucares-benzocarbazoldionas-polihidroxiladas-beta-aminoacidos-cicloalcanicos\/","title":{"rendered":"S\u00edntesis y evaluaci\u00f3n biol\u00f3gica de inhibidores pept\u00eddicos de la beta-secretasa y de nuevos derivados de nitroaz\u00facares (benzocarbazoldionas polihidroxiladas, beta-amino\u00e1cidos cicloalc\u00e1nicos polihidroxilados e iminoaz\u00facares ramificados)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel Otero Casas <\/strong><\/h2>\n<p>En esta tesis doctoral se han desarrollado nuevas aplicaciones  sint\u00e9ticas de hidratos de carbono encaminadas a la s\u00edntesis de inhibidores pept\u00eddicos de la beta-secretasa, enzima que interviene en el desarrollo de la enfermedad de alzheimer, as\u00ed como a la s\u00edntesis de benzocarbazoldionas polihidroxiladas, beta-amino\u00e1cidos cicloalc\u00e1nicos polihidroxilados e iminoaz\u00facares ramificados. La s\u00edntesis de inhibidores pept\u00eddicos de la beta-secretasa se bas\u00f3 en la aplicaci\u00f3n de reacciones sencillas de transformaci\u00f3n de delta-lactonas y hexofuranosas en los is\u00f3steros que forman parte de los inhibidores. La evaluaci\u00f3n biol\u00f3gica de los inhibidores obtenidos tambi\u00e9n fu\u00e9 llevada a cabo, obteniendo resultados interesantes de inhibici\u00f3n de la beta-secretasa.  En la segunda parte de la tesis se desarrollaron nuevas aplicaciones sint\u00e9ticas de nitroaz\u00facares, basadas en la reacci\u00f3n de michael de adici\u00f3n de nucle\u00f3filos a nitroolefinas y en la reacci\u00f3n de henry intramolecular de nitroaldeh\u00eddos para generar nitrociclohexanos. La aplicaci\u00f3n de estas reacciones a nitroolefinas derivadas de aldohexosas nos permiti\u00f3 establecer nuevos m\u00e9todos de s\u00edntesis de benzocarbazoldionas polihidroxiladas y de beta-amino\u00e1cidos ciclohex\u00e1nicos y ciclopent\u00e1nicos polihidroxilados, compuestos novedosos cuya s\u00edntesis no haba sido descrita hasta el momento. La aplicaci\u00f3n de la doble condensaci\u00f3n de henry de nitroaz\u00facares con formaldeh\u00eddo nos ha permitido establecer un m\u00e9todo para la preparaci\u00f3n de iminoaz\u00facares ramificados de cinco y siete miembros, con actividad como inhibidores de glicosidasas, la cual tambi\u00e9n ha sido medida en el transcurso de este trabajo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis y evaluaci\u00f3n biol\u00f3gica de inhibidores pept\u00eddicos de la beta-secretasa y de nuevos derivados de nitroaz\u00facares (benzocarbazoldionas polihidroxiladas, beta-amino\u00e1cidos cicloalc\u00e1nicos polihidroxilados e iminoaz\u00facares ramificados)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis y evaluaci\u00f3n biol\u00f3gica de inhibidores pept\u00eddicos de la beta-secretasa y de nuevos derivados de nitroaz\u00facares (benzocarbazoldionas polihidroxiladas, beta-amino\u00e1cidos cicloalc\u00e1nicos polihidroxilados e iminoaz\u00facares ramificados) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel Otero Casas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Estevez Cabanas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Mouri\u00f1o mosquera <\/li>\n<li>sergio Castillon miranda (vocal)<\/li>\n<li> Fleet george william john (vocal)<\/li>\n<li>pilar Rauter amelia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel Otero Casas En esta tesis doctoral se han desarrollado nuevas aplicaciones sint\u00e9ticas de hidratos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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