{"id":57926,"date":"2018-03-09T22:45:46","date_gmt":"2018-03-09T22:45:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-farmacos-anestesicos-locales-sobre-canales-herg-y-kv1-5-consecuencias-farmacologicas-del-ensamblaje-con-subunidades-beta\/"},"modified":"2018-03-09T22:45:46","modified_gmt":"2018-03-09T22:45:46","slug":"efectos-de-farmacos-anestesicos-locales-sobre-canales-herg-y-kv1-5-consecuencias-farmacologicas-del-ensamblaje-con-subunidades-beta","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/efectos-de-farmacos-anestesicos-locales-sobre-canales-herg-y-kv1-5-consecuencias-farmacologicas-del-ensamblaje-con-subunidades-beta\/","title":{"rendered":"Efectos de f\u00e1rmacos anest\u00e9sicos locales sobre canales herg y kv1.5. consecuencias farmacol\u00f3gicas del ensamblaje con subunidades beta"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Arias S\u00e1nchez <\/strong><\/h2>\n<p>La presente tesis doctoral estudia:     1,- los efectos y la estereoselectividad de la bupivaca\u00edna y de la ropivaca\u00edna sobre los canales de potasio herg.     2,- la estereoselectividad del bloqueo delos canales kv1.5 ensamblados o no con la subunidad kvbeta1.3.     3,- las consecuencias farmacol\u00f3gicas del ensamblaje de los canales kv1.5 con la subunidad kvbeta2.1.     4,- los efectos que dos mutaciones en la cara externa del canal kv1.5 produc\u00edan sobre las acciones de un derivado permanentemente cargado de la bupivaca\u00edna (rb+1c).     para ello, se registraron las corrientes i\u00f3nica a trav\u00e9s de los canales herg y kv1.5 utilizando la t\u00e9cnica de fijaci\u00f3n de voltaje en parches de membrana en c\u00e9lulas ltk- y hek293 transfectadas con el adn codificante de cada canal.     los resultados obtenidos demuestran que:     1,- los anest\u00e9sicos locales estudiados bloquean los canales herg de forma estereoselectiva, siendo el enanti\u00f3mero s(-) m\u00e1s potente que el r(+).     2,- el grado de estereoselectividad del bloqueo de los canales kv1.5 producido por la bupivaca\u00edna disminuy\u00f3 de 10 a 4 (en ausencia y en presencia de kvbeta1.3 debido a modificaciones en la ci\u00e9tica de asociaci\u00f3n y disociaci\u00f3n.     3,- las caracter\u00edsticas del bloqueo del os canales kv1.5 expresados en c\u00e9lulas ltk- producido por la rb+1c en presencia de latas concentraciones de potasio (140 mm) en la soluci\u00f3n externa est\u00e1n reguladas por la subunidad kvbeta2.1 que estas c\u00e9lulas expresan de forma end\u00f3gena.     4,- los efectos de la rb+1c sobre los canales kv1.5 y kv2.1 pueden se atribuidos a su interacci\u00f3n con un triplete de amino\u00e1cidos (nqg en kv1.5, edd en kv2.1) localizados en el vest\u00edbulo externo de estos canales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de f\u00e1rmacos anest\u00e9sicos locales sobre canales herg y kv1.5. consecuencias farmacol\u00f3gicas del ensamblaje con subunidades beta<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de f\u00e1rmacos anest\u00e9sicos locales sobre canales herg y kv1.5. consecuencias farmacol\u00f3gicas del ensamblaje con subunidades beta <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Arias S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Valenzuela Miranda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Luis Tamargo men\u00e9ndez <\/li>\n<li>soledad Calvo Martinez (vocal)<\/li>\n<li>Antonio Felipe campo (vocal)<\/li>\n<li>sebasti\u00e1n Cerd\u00e1n Garc\u00eda-esteller (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Arias S\u00e1nchez La presente tesis doctoral estudia: 1,- los efectos y la estereoselectividad de la bupivaca\u00edna [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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