{"id":57943,"date":"2018-03-09T22:45:46","date_gmt":"2018-03-09T22:45:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-biologica-de-la-leucemia-mieloide-aguda-con-translocacion-t816p11p13-y-reordenamiento-myst3-crebbp\/"},"modified":"2018-03-09T22:45:46","modified_gmt":"2018-03-09T22:45:46","slug":"caracterizacion-biologica-de-la-leucemia-mieloide-aguda-con-translocacion-t816p11p13-y-reordenamiento-myst3-crebbp","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hemopatologia\/caracterizacion-biologica-de-la-leucemia-mieloide-aguda-con-translocacion-t816p11p13-y-reordenamiento-myst3-crebbp\/","title":{"rendered":"Caracterizaci\u00f3n biol\u00f3gica de la leucemia mieloide aguda con translocaci\u00f3n t(8;16)(p11;p13) y reordenamiento myst3-crebbp"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mireia Cam\u00f3s Guijosa <\/strong><\/h2>\n<p>Introducci\u00f3n     la leucemia mieloide aguda (lma) es una enfermedad heterog\u00e9nea desde el punto de vista cl\u00ednico y biol\u00f3gico. En los \u00faltimos a\u00f1os se vienen reconociendo diversas alteraciones moleculares que definen entidades especificas. En este contexto, la lma con translocaci\u00f3n t(8;16)(p11;p13) y reordenamiento myst3 (moz)\/crebbp(cbp) es una variedad infrecuente mal caracterizada desde el punto de vista biol\u00f3gico.  hip\u00f3tesis y objetivos     la prote\u00edna quim\u00e9rica myst3-crebbp, resultante de la translocaci\u00f3n t(8;16)(p11,p13), podr\u00eda conferir a este subtipo de lma una individualidad biol\u00f3gica propia, con rasgos diferenciados respecto al resto de leucemia. Para confirmar esta hip\u00f3tesis general los objetivos de la presente tesis doctoral fueron:     1,- dise\u00f1ar una t\u00e9cnica de pcr para el diagnostico r\u00e1pido y espec\u00edfico del reordenamiento myst3-crebbp.     2,- caracterizar el punto de ruptura de los genes implicados en la translocaci\u00f3n en una serie de pacientes.     3,- estudiar el perfil de expresi\u00f3n g\u00e9nica de las lma con reordenamiento myst3-crebbp y compararlo con el de otros subtipos bien definidos de lma.  pacientes y m\u00e9todos     se estudi\u00f3 una serie de pacientes con lma y reordenamiento myst3-crebbp (n=7) y se compararon sus caracter\u00edstica biol\u00f3gicas con otros casos de lma. Para ello se dise\u00f1\u00f3 una t\u00e9cnica de pcr nueva para la detecci\u00f3n del reordenamiento myst3-crebbp, mientras que los puntos de ruptura de los genes implicados en la translocaci\u00f3n se estudiaron mediante secuenciaci\u00f3n directa. El estudio del perfil de expresi\u00f3n g\u00e9nica de la lma con reordenamiento myst3-crebbp se abord\u00f3 utilizando microarrays de oligonucle\u00f3tidos (affmetrix hu133a). La diferencia entre la expresi\u00f3n g\u00e9nica  entre diferentes subtipos de leucemia se analiz\u00f3 con diversas t\u00e9cnicas estad\u00edsticas (anova, t-test), utilizando diferentes programas inform\u00e1ticos. Los resultados de este an\u00e1lisis se validaron en una serie independiente de paci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n biol\u00f3gica de la leucemia mieloide aguda con translocaci\u00f3n t(8;16)(p11;p13) y reordenamiento myst3-crebbp<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n biol\u00f3gica de la leucemia mieloide aguda con translocaci\u00f3n t(8;16)(p11;p13) y reordenamiento myst3-crebbp <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mireia Cam\u00f3s Guijosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Esteve Reyner<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Sanz Alonso <\/li>\n<li>Salut Brunet Mauri (vocal)<\/li>\n<li>Norma Carmen Gutierrez Gutierrez (vocal)<\/li>\n<li>Francesco Lo-coco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mireia Cam\u00f3s Guijosa Introducci\u00f3n la leucemia mieloide aguda (lma) es una enfermedad heterog\u00e9nea desde el punto de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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