{"id":58100,"date":"2018-03-09T22:45:54","date_gmt":"2018-03-09T22:45:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-sesquiterpenos-biologicamente-aislados-de-massarina-tunicata-ampuliferina-sp-27-y-lycopersicon-hirsulum\/"},"modified":"2018-03-09T22:45:54","modified_gmt":"2018-03-09T22:45:54","slug":"sa%c2%adntesis-de-sesquiterpenos-biologicamente-aislados-de-massarina-tunicata-ampuliferina-sp-27-y-lycopersicon-hirsulum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/sa%c2%adntesis-de-sesquiterpenos-biologicamente-aislados-de-massarina-tunicata-ampuliferina-sp-27-y-lycopersicon-hirsulum\/","title":{"rendered":"S\u00edntesis de sesquiterpenos biol\u00f3gicamente aislados de massarina tunicata, ampuliferina sp. 27 y lycopersicon hirsulum"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Rodriguez Lopez <\/strong><\/h2>\n<p>En este trabajo de investigaci\u00f3n se ha llevado a cabo un estudio sint\u00e9tico encaminado a la s\u00edntesis total de los sesquiterpenoides bioactivos (+)-massarinolina b, (+)-massarinolina c, (+)-pinthunamida y los \u00e1cidos \u00c2\u00bf y \u00edY bergamoten\u00f3icos. estos diterpenos han demostrado tener una marcada actividad biol\u00f3gica, como bactericidas y reguladores del crecimiento en plantas.  presentan en su estructura sistemas tric\u00edclicos poco corrientes. No existe precedente alguno de la s\u00edntesis de (+)-massarinolina b y (+)-massarinolina c. Tanto la s\u00edntesis de (+)-pinthunamida como la de los \u00e1cidos \u00c2\u00bf y \u00edY bergamoten\u00f3icos cuentan con un \u00fanico precedente debido a k. Mori.  en el an\u00e1lisis retrosint\u00e9tico propuesto para estos compuestos se emplea como material de partida r-(-)-carvona, lo que adem\u00e1s nos permitir\u00e1 establecer sus configuraciones absolutas. la etapa clave en la s\u00edntesis de los compuestos (+)-massarinolina b, (+)-massarinolina c, (+)-pinthunamida es una reacci\u00f3n de acoplamiento cruzado entre un aldeh\u00eddo sintetizado a partir de la r-(-)-carvona y un e-\u00edY-yodometacrilato, reacci\u00f3n promovida por el par cr\/ni y llevada a cabo bajo las condiciones descritas por nozaki-hiyama-kishi. por otro lado, en la s\u00edntesis de los \u00e1cidos \u00c2\u00bf y \u00edY  bergamoten\u00f3icos la etapa clave es la reacci\u00f3n de acoplamiento entre el vinileter sintetizado a partir de la r-(-)-carvona y un e-\u00edY-yodometacrilato, reacci\u00f3n llevada a cabo bajo las condiciones descritas por suzuki-miyaura. por lo tanto se han llevado a cabo las s\u00edntesis totales de los sesquiterpenoides bioactivos (+)-massarinolina b, (+)-massarinolina c, (+)-pinthunamida y el \u00e1cido \u00edY-(e)-endo-bergamotenoico determinando su configuraci\u00f3n absoluta partiendo de r-(-)-carvona y siguiendo secuencias sint\u00e9ticas con reacciones estereocontroladas. A su vez estas secuencias sint\u00e9ticas nos han permitido llevar a cabo un estudio exhaustivo de las reacciones de acoplamiento catalizadas por cr\/ni (reacci\u00f3n de nozaki-hiyama-kishi) y por pd (reacci\u00f3n de suzuki-miyaura).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de sesquiterpenos biol\u00f3gicamente aislados de massarina tunicata, ampuliferina sp. 27 y lycopersicon hirsulum<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de sesquiterpenos biol\u00f3gicamente aislados de massarina tunicata, ampuliferina sp. 27 y lycopersicon hirsulum <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Rodriguez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Bermejo Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Suau suarez <\/li>\n<li>ricardo Alonso alonso (vocal)<\/li>\n<li>Francisco Jos\u00e9 Pulido pelaz (vocal)<\/li>\n<li>joaqu\u00edn Rodr\u00edguez mor\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Rodriguez Lopez En este trabajo de investigaci\u00f3n se ha llevado a cabo un estudio sint\u00e9tico encaminado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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